Klose, Johannes; Trefz, Stefan; Wagner, Tobias; Steffen, Luca; Preissendoerfer Charrier, Arsalie; Radhakrishnan, Praveen; Volz, Claudia; Schmidt, Thomas; Ulrich, Alexis; Dieter, Sebastian M.; Ball, Claudia; Glimm, Hanno; Schneider, Martin published the artcile< Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model>, SDS of cas: 1492-18-8, the main research area is colorectal cancer salinomycin fluorouracil oxaliplatin antitumoral combination therapy.
Objectives: Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods: Primary tumor-initiating cells isolated from human patients with colorectal liver metastases or from human primary colon carcinoma were exposed to salinomycin and compared to treatment with 5-FU and oxaliplatin. TICs were injected s.c. into NOD/SCID mice to induce a patient-derived mouse xenograft model of colorectal cancer. Animals were treated either with salinomycin, FOLFOX regimen, or salinomycin and FOLFOX. Results: Applying TICs isolated from human patients with colorectal liver metastases or from human primary colon carcinoma, we demonstrated that salinomycin exerts increased antiproliferative activity compared to 5-fluorouracil and oxaliplatin treatment. Consistently, salinomycin alone or in combination with FOLFOX exerts superior antitumor activity compared to FOLFOX therapy in a patient-derived mouse xenograft model of colorectal cancer. Salinomycin induces apoptosis of human colorectal cancer cells, accompanied by accumulation of dysfunctional mitochondria and reactive oxygen species. Conclusion: Collectively, the results of this pre-clin. study indicate that salinomycin alone or in combination with 5-fluorouracil and oxaliplatin exerts increased antitumoral activity compared to common chemotherapy.
PLoS One published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, SDS of cas: 1492-18-8.
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