Singer, M. V.; Schmausser, H.; Schoenfeld, G. published the artcile< Efficacy and tolerability of olsalazine (dipentum) in the treatment of patients with ulcerative colitis-results of a field study>, Formula: C14H8N2Na2O6, the main research area is Dipentum ulcerative colitis.
Background/Aims: In the treatment of ulcerative colitis, 5-aminosalicylic acid is the standard therapy for both acute exacerbations of the disease and the maintenance of remission. Clin. studies have shown that olsalazine (Dipentum) – a prodrug converted to two mols. of 5-ASA by colonic bacteria – induces and maintains remission. This study aimed to investigate the efficacy and tolerability of olsalazine in patients with ulcerative colitis who were being treated in daily practice by private physicians specializing in gastroenterol. Methodol.: A total of 260 patients with ulcerative colitis (aged 17-77 years, 116 men) were studied. The doses of olsalazine and the clin. data (including acute disease symptoms and the occurrence of adverse events) were recorded over a 6-mo period. Results: Twenty per cent of patients had pancolitis, 48% had left-sided disease and 32% had proctitis or proctosigmoiditis. At study entry, 86% of patients had active disease; the percentages of these patients in remission after 6 wk and 6 mo were 42% and 91%, resp. Patients with active disease received a mean dose of olsalazine – 2324mg per day initially and 1325mg per day at 6 mo. The corresponding figures for patients in remission at study entry were 1386mg and 1162mg per day, resp. Seventy-three per cent of patients took olsalazine with food, as recommended. The overall rate of adverse events was low; no serious adverse events occurred. Conclusions: Olsalazine therapy resulted in a rapid regression in the acute symptoms of ulcerative colitis. Olsalazine was also effective in maintaining remission. The drug was well tolerated.
Hepato-Gastroenterology published new progress about Gastrointestinal agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Formula: C14H8N2Na2O6.
Referemce:
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Alcohols – Chemistry LibreTexts