Zhang, Youcan; Geng, Hui-Qing; Wu, Xiao-Feng published the artcile< Palladium-Catalyzed Carbonylative Four-Component Synthesis of β-Perfluoroalkyl Amides>, SDS of cas: 627-27-0, the main research area is perfluoroalkyl amide preparation chemoselective; alkene perfluoroalkyl halide amine perfluoroalkylation aminocarbonylation tandem; aminocarbonylation; multicomponent reaction; palladium catalyst; perfluoroalkylation; β-perfluoroalkyl amides.
Transition-metal-catalyzed multicomponent carbonylation is one of the most efficient strategies to construct carbonyl-containing compounds Herein, a palladium-catalyzed four-component perfluoroalkylation/aminocarbonylation of unactivated alkenes with perfluoroalkyl halides, and amines was developed. A wide range of substrates, including anilines, alkylamines, sulfonamides, and hydrazines are all suitable reaction partners for this catalyst system, resulting in various β-perfluoroalkyl amides with good functional-group tolerance and excellent chemoselectivity. Furthermore, not only alkyl olefins, but also aliphatic alkynes, and even alkyl allenes can all be employed. Notably, several medical and bioactive related mols. are compatible here as well.
Chemistry – A European Journal published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts