Zhu, Han; Cao, Chujin; Wu, Zhongcai; Zhang, Heping; Sun, Zhihong; Wang, Meng; Xu, Huzi; Zhao, Zhi; Wang, Yuxi; Pei, Guangchang; Yang, Qian; Zhu, Fengming; Yang, Juan; Deng, Xuan; Hong, Yu; Li, Yinzheng; Sun, Jie; Zhu, Fan; Shi, Mengxia; Qian, Kun; Ye, Ting; Zuo, Xuezhi; Zhao, Fenfei; Guo, Jing; Xu, Gang; Yao, Ying; Zeng, Rui published the artcile< The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease>, Quality Control of 87-73-0, the main research area is Lactobacillus casei acute chronic kidney disease progression; Lactobacillus casei Zhang; acute kidney injury; chronic kidney disease; gut microbiota; nicotinamide; short-chain fatty acids.
The relationship between gut microbial dysbiosis and acute or chronic kidney disease (CKD) is still unclear. Here, we show that oral administration of the probiotic Lactobacillus casei Zhang (L. casei Zhang) corrected bilateral renal ischemia-reperfusion (I/R)-induced gut microbial dysbiosis, alleviated kidney injury, and delayed its progression to CKD in mice. L. casei Zhang elevated the levels of short-chain fatty acids (SCFAs) and nicotinamide in the serum and kidney, resulting in reduced renal inflammation and damage to renal tubular epithelial cells. We also performed a 1-yr phase 1 placebo-controlled study of oral L. casei Zhang use (Chinese clin. trial registry, ChiCTR-INR-17013952), which was well tolerated and slowed the decline of kidney function in individuals with stage 3-5 CKD. These results show that oral administration of L. casei Zhang, by altering SCFAs and nicotinamide metabolism, is a potential therapy to mitigate kidney injury and slow the progression of renal decline.
Cell Metabolism published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Quality Control of 87-73-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts