Electric Literature of 10029-04-6, Adding some certain compound to certain chemical reactions, such as: 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate,molecular formula is C6H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10029-04-6.
Example 1(0189)With reference to FIG. 1, the first generic compound in the synthetic sequence (structure I) is prepared where X is CN, W is H, X? is CO2Et, and L is H.(0190)More specifically, in a 1 liter three-necked flask, alpha(hydroxymethyl)ethylacrylate (260.0 g, 2.0 mol) and 1.1 equivalent of cyanoacetic acid (187.0 g, 2.2 mol) were suspended in toluene (420 mL) with hydroquinone (0.8 g). The mixture was heated at a temperature of 90 C. until the cyanoacetic acid melted, at which point a catalytic amount (two drops) of sulfuric acid was added. The reaction mixture was stirred with heating at a temperature of 125 C. with a Dean-Stark apparatus attached to remove the water.(0191)The reaction mixture was washed with dilute aqueous sodium bicarbonate to remove excess cyanoacetic acid, then with dilute hydrochloric acid and finally with brine. The solvent (toluene) was removed under reduced pressure and the residue with an added 1 g of hydroquinone was distilled (b.p. 130 C. at 0.2 mm Hg) to furnish 197 g of the final product in a yield of 51%. Spectral confirmation is given below.(0192)1H-NMR (60 MHz, CDCl3): delta=1.32 (t, 3H), 3.49 (s, 2H), 4.24 (q, 2H), 4.92 (s, 2H), 5.90 (s, 1H), 6.41 (s, 1H) ppm.(0193)FT-IR (film): 2983.1, 2929.4, 2259.3, 1750.8, 1712.7, 1638.8, 1447.4, 1395.9, 1367.9, 1336.0, 1309.1, 1270.0, 1176.4, 1152.9, 1023.5, 957.7, 879.3, 859.1, 815.9 cm-1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10029-04-6, Ethyl 2-(hydroxymethyl)acrylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Henkel Ireland Limited; Gherardi, Stefano; McArdle, Ciaran B.; Faimani, Giovanni; Loschen, Christoph; US8399698; (2013); B1;,
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