Yuan, Zi-Bo; Fang, Hong-Bo; Feng, Quan-Kai; Li, Tao; Li, Jie published the artcile< Prognostic factors of recurrent intrahepatic cholangiocarcinoma after hepatectomy: A retrospective study>, Electric Literature of 1492-18-8, the main research area is intrahepatic cholangiocarcinoma hepatectomy cancer recurrence prognosis chemotherapy; Hepatectomy; Intrahepatic cholangiocarcinoma; Multimodality therapy; Prognosis; Recurrence.
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor. Hepatectomy is an effective treatment for early ICC, but postoperative recurrence greatly affects patient survival. Studies on recurrent ICC after hepatectomy are lacking. AIM To investigate the clin. characteristics of patients with recurrent ICC after hepatectomy, analyze prognostic factors and explore diagnosis and treatment strategies. A retrospective anal. was performed on all ICC patients undergoing hepatectomy from Jan. 2013 to August 2021. Patients with postoperative recurrence were selected according to the inclusion and exclusion criteria. Cumulative overall survival was plotted by the Kaplan-Meier method, and differences were assessed by univariate survival anal. using the log-rank test. Multivariate anal. of cumulative survival was performed using the Cox proportional risk model. During the 8-yr study period, 103 patients underwent ICC-related hepatectomy, and 54 exhibited postoperative recurrence. The median disease-free survival (DFS) was 6 mo, the median overall survival (OS) was 9 mo, and the cumulative OS rates at 1, 2 and 3 years after the operation were 40.7%, 14.8% and 7.4%, resp. The median OS after recurrence was 4 mo, and the cumulative OS rates at 1, 2 and 3 years after recurrence were 16.1%, 6.7% and 3.4%, resp. Multivariate anal. showed that alc. consumption [hazard ratio (HR) = 4.64, 95% confidence interval (CI): 1.53-14.04, P = 0.007] and DFS < 6 mo (HR = 3.47, 95%CI: 1.59-7.60, P = 0.002) were independent risk factors for the cumulative survival of patients with recurrence, while treatment after recurrence (HR = 0.21, 95%CI: 0.08-0.55, P = 0.001) was an independent protective factor. The median OS time of patients receiving multimodality therapy after recurrence of ICC was 7 mo, which was significantly higher than that of patients receiving only local therapy (3 mo), patients receiving systematic therapy (4 mo) and patients receiving the best supportive therapy (1 mo). Patients with recurrent ICC who received multimodality therapy had a significantly better long-term survival after recurrence than those who did not (P = 0.026). The prognosis of patients with recurrence after ICC-related hepatectomy is poor. Alc. consumption and DFS < 6 mo are independent risk factors in terms of the cumulative survival of patients with recurrence, while treatment after recurrence is an independent protective factor. Multimodality therapy can effectively improve the prognosis of patients. World Journal of Gastroenterology published new progress about Cancer antigen 19-9 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Electric Literature of 1492-18-8.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts