Ng, Teng Wei; Liao, Gang; Lau, Kai Kiat; Pan, Hui-Jie; Zhao, Yu published the artcile< Room-Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity>, Electric Literature of 403-41-8, the main research area is secondary alc preparation Guerbet catalyst enantioselectivity; Guerbet reaction; alkylation; borrowing hydrogen; enantioselectivity; higher-order alcohols.
The authors report herein an unprecedented highly efficient Guerbet-type reaction at room temperature (catalytic TON up to >6000). This β-alkylation of secondary Me carbinols with primary alcs. has significant advantage of delivering higher-order secondary alcs. in an economical, redox-neutral fashion. In addition, the first enantioselective Guerbet reaction also was achieved using a com. available chiral ruthenium complex to deliver secondary alcs. with moderate yield and up to 92% ee. In both reactions, the use of a traceless ketone promoter proved to be beneficial for the catalytic efficiency.
Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (Me carbinols). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts