Sandberg-Gertzen, H.; Ryde, M.; Jaernerot, G. published the artcile< Absorption and excretion of azodisal sodium and its metabolites in man after rectal administration of a single 2-g dose>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is azodisal sodium pharmacokinetics.
The behavior of azodisal sodium (ADS)(I) [6054-98-4] and its metabolites after a single 2-g rectal dose was investigated in 10 healthy volunteers. Blood samples were drawn frequently, and urine was collected during intervals of 24 h. The ADS absorption gave a mean peak serum concentration of 2.1 μg/mL. The urinary excretion of ADS was 0.8% of the given dose. After rectal administration, 5-aminosalicylic acid (5-ASA) [89-57-6] could be detected in the serum only in 2 of the subjects, with a mean concentration of <0.5 μg/mL. N-Acetyl-5-aminosalicylic acid [51-59-2] was present in increasing serum concentrations, being 0.93 μg/mL at 24 h. The mean 24-h urinary excretion of these 2 metabolites was only 2.7% of the given dose. In another study, the azo bond of ADS has been shown to be split by anaerobic and aerobic bacteria. The low absorption of its metabolites indicates that ADS is a suitable mol. for delivering the presumed pharmacol. active moiety, 5-ASA. Scandinavian Journal of Gastroenterology published new progress about Rectum. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts