Sofferman, Danielle L.; Konar, Arkaprabha; Spears, Kenneth G.; Sension, Roseanne J. published the artcile< Ultrafast excited state dynamics of provitamin D3 and analogs in solution and in lipid bilayers>, Computed Properties of 434-16-2, the main research area is dynamic provitamin lipid bilayer.
The photochem. ring-opening reaction of 7-dehydrocholesterol (DHC, provitamin D3) is responsible for the light-initiated formation of vitamin D3 in mammalian skin membranes. Visible transient absorption spectroscopy was used to explore the excited state dynamics of DHC and two analogs: ergosterol (provitamin D2) and DHC acetate free in solution and confined to lipid bilayers chosen to model the biol. cell membrane. In solution, the excited state dynamics of the three compounds are nearly identical. However, when confined to lipid bilayers, the heterogeneity of the lipid membrane and packing forces imposed on the mol. by the lipid alter the excited state dynamics of these compounds When confined to lipid bilayers in liposomes formed using DPPC, two solvation environments are identified. The excited state dynamics for DHC and analogs in fluid-like regions of the liposome membrane undergo internal conversion and ring-opening on 1 ps-2 ps time scales, similar to those observed in isotropic solution In contrast, the excited state lifetime of a subpopulation in regions of lower fluidity is 7 ps-12 ps. The long decay component is unique to these liposomes and results from the structural properties of the lipid bilayer. Addnl. measurements in liposomes prepared with lipids having slightly longer or shorter alkane tails support this conclusion. In the lipid environments studied, the longest lifetimes are observed for DHC. The unsaturated sterol tail of ergosterol and the acetate group of DHC acetate disrupt the packing around the mol. and permit faster internal conversion and relaxation back to the ground state. (c) 2021 American Institute of Physics.
Journal of Chemical Physics published new progress about Bilayer biological membrane (lipid). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Computed Properties of 434-16-2.
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