Related Products of 2566-44-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2566-44-1 as follows.
Reaction A : Dissolve oxalyl chloride (9.3 mL, 106.7 mmol) in dichloromethane (140 mL) at ambient temperature, then cool to-78C and add slowly a solution of DMSO (11.22 g, 143.6 mmol) in dichloromethane (20 mL) while venting the mixture and stir the reaction at-78C for 20 minutes. Add 2-cyclopropyl-ethanol (6.11 g, 71.21 mmol) in dichloromethane (20 mL). Warm to 0C and add dichloromethane (25 mL) to assist with stirring and mix for 30 minutes. Dilute this reaction mixture with 100 mL THF and pour into a cold (-78C) solution of Reaction B. Reaction B : Add a solution of tert-butyl acetate (62 mL, 424 mmol) in THF (60 mL) to a cold solution (-78C) of lithium diisopropylamine (2M in heptanes/tetrahydrofuran/ethylbenzene, 180 mL, 360 mmol) in anhydrous THF (700 mL) and stir at-78C for 1.5-2 hours. Add crude Reaction A prepared as described above and rinse with 100 mL anhydrous THF. Stir at-78C for 1.5 hours then add water/diethyl ether and warm to ambient temperature overnight. Separate the layers and extract the aqueous layer with diethyl ether (3x). Dry the combined organic extracts over anhydrous MgS04, filter, and concentrate in vacuo. Purify the reaction on silica gel eluting with 20% EtOAc/hexanes to give 4-cyclopropyl-3-hydroxy-butyric acid tert butyl ester (10. 65 g. 75%).’H NMR (CDC13) 6 4.11-4. 05 (m, 1H), 3. 12 (d, 1H), 2.53 (dd, 1H), 2.38 (dd, 1H), 1. 60- 1.48 (m, 1H), 1.47 (s, 9H), 1.32-1. 23 (m, 1H), 0.80-0. 73 (m, 1H), 0.51-0. 46 (m, 2H), 0. 13-0. 04 (m, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2566-44-1, its application will become more common.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/92835; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts