Mohamed, Maged E.; Abduldaium, Yamen S.; Younis, Nancy S. published the artcile< Ameliorative effect of linalool in cisplatin-induced nephrotoxicity: the role of HMGB1/TLR4/NF-κB and Nrf2/HO1 pathways>, Safety of 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is linalool cisplatin induced nephrotoxicity ameliorative effect; apoptosis; essential oil; human cell line cytotoxicity; monoterpenes; oxidative stress; toll-like receptors.
The monoterpene linalool is a well-known essential oil component produced by several aromatic plants. Cisplatin is a widely used anticancer drug that produces many side effects, particularly nephrotoxicity. Here, we aimed to inspect linalool′s protective activity against cisplatin-induced nephrotoxicity and explore part of the underlying mechanisms. Male Wistar rats were given linalool (50 and 100 mg/kg/day orally) for 15 days; then challenged with cisplatin (8 mg/kg) on the 12th day. Renal function parameters, oxidative stress, inflammatory and apoptotic markers, and toll-like receptor pathway gene, and protein expressions were investigated. Histopathol., immunohistochem., and cell-line mediated cytotoxicity assays were conducted. Linalool ameliorated kidney function after cisplatin challenge and managed all oxidation system parameters including GSH, SOD, CAT, MDA, NADPH, and particularly the Nrf2-mediated pathway markers. Linalool decreased TLR4, MYD88 and TRIF gene and protein expressions; diminished related inflammatory mediators such as TNF-α, IL-1β, IL-6, and NF-κB; and down-regulated HMBG1. Linalool mitigated cisplatin-induced apoptotic markers such as caspase 3, caspase 9, and Bax expression, and boosted the anti-apoptotic Bcl2 expression. Linalool potentiated the cytotoxic effect of cisplatin when investigated on HeLa and PC3 human cancer cell lines. Linalool could protect against cisplatin-induced kidney function and tissue damage.
Biomolecules published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (Bax). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Safety of 3,7-Dimethylocta-1,6-dien-3-ol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts