Anderson, Allison; Genaro-Mattos, Thiago C.; Allen, Luke B.; Koczok, Katalin; Korade, Zeljka; Mirnics, Karoly published the artcile< Interaction of maternal immune activation and genetic interneuronal inhibition>, Product Details of C27H44O, the main research area is Gad1 neuropeptide Y maternal immune activation genetic interneuronal inhibition; Acylcarnitines; Interneuron; Maternal immune activation; Neuroinflammation; Schizophrenia; Sterol profile.
Genes and environment interact during intrauterine life, and potentially alter the developmental trajectory of the brain. This can result in life-long consequences on brain function. We have previously developed two transgenic mouse lines that suppress Gad1 expression in parvalbumin (PVALB) and neuropeptide Y (NPY) expressing interneuron populations using a bacterial artificial chromosome (BAC)-driven miRNA-based silencing technol. We were interested to assess if maternal immune activation (MIA), genetic interneuronal inhibition, and the combination of these two factors disrupt and result in long-term changes in neuroinflammatory gene expression, sterol biosynthesis, and acylcarnitine levels in the brain of maternally exposed offspring. Pregnant female WT mice were given a single i.p. injection of saline or polyinosinic-polycytidilic acid [poly(I:C)] at E12.5. Brains of offspring were analyzed at postnatal day 90. We identified complex and persistent neuroinflammatory gene expression changes in the hippocampi of MIA-exposed offspring, as well in the hippocampi of Npy/Gad1 and Pvalb/Gad1 mice. In addition, both MIA and genetic inhibition altered the post-lanosterol sterol biosynthesis in the neocortex and disrupted the typical acylcarnitine profile. In conclusion, our findings suggest that both MIA and inhibition of interneuronal function have long-term consequences on critical homeostatic mechanisms of the brain, including immune function, sterol levels, and energy metabolism
Brain Research published new progress about Acylcarnitines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Product Details of C27H44O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts