Xiao, Heng; Chen, Chun; Li, Chao; Huang, Qiang; Fu, Xiong published the artcile< Physicochemical characterization, antioxidant and hypoglycemic activities of selenized polysaccharides from Sargassum pallidum>, Electric Literature of 3458-28-4, the main research area is Sargassum selenium polysaccharide physicochem antioxidant hypoglycemic; Antioxidant; Hypoglycemic; Polysaccharide; Selenylation; Structure.
This study was carried out to study the effects of selenylation on physicochem. and biol. properties of polysaccharide (SPP) extracted from Sargassum pallidum. The selenized derivative of SPP (Se-SPP) with the selenium content of 2419 μg/g was synthesized by sodium selenite/dilute nitric acid method. Physicochem. characterization indicated that selenylation modification resulted in some changes in chem. composition, monosaccharide composition, mol. weight and surface morphol. of polysaccharides. FT-IR spectroscopy showed that a new absorption peak appeared at 675 cm-1 in Se-SPP probably due to the substitution of selenyl groups. Bioactivity assay showed that Se-SPP exhibited higher scavenging radical activities and ferrous ion chelating activities than native SPP. Compared with SPP and acarbose, Se-SPP showed more significantly inhibitory effect on α-glucosidase activity in a noncompetitive inhibition type. The IC50 values of SPP, Se-SPP and acarbose were determined as 1.579, 0.896 and 2.742 mg/mL, resp. These results suggest that Se-SPP can be used to develop a new selenium-complementary ingredient in functional foods.
International Journal of Biological Macromolecules published new progress about Antidiabetic agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.
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