Moons, Sam J.; Rossing, Emiel; Heming, Jurriaan J. A.; Janssen, Mathilde A. C. H.; van Scherpenzeel, Monique; Lefeber, Dirk J.; de Jonge, Marien I.; Langereis, Jeroen D.; Boltje, Thomas J. published the artcile< Structure-Activity Relationship of Fluorinated Sialic Acid Inhibitors for Bacterial Sialylation>, Synthetic Route of 5505-63-5, the main research area is mannosamine fluorosialic acid synthesis antibacterial SAR Haemophilus influenzae sialylation.
Bacterial pathogens such as Nontypeable Haemophilus influenzae (NTHi) can evade the immune system by taking up and presenting host-derived sialic acids. Herein, we report a detailed structure-activity relationship of sialic acid-based inhibitors that prevent the transfer of host sialic acids to NTHi. We report the synthesis and biol. evaluation of C-5, C-8, and C-9 derivatives of the parent compound 3-fluorosialic acid (SiaNFAc). Small modifications are tolerated at the C-5 and C-9 positions, while the C-8 position does not allow for modification. These structure-activity relationships define the chem. space available to develop selective bacterial sialylation inhibitors.
Bioconjugate Chemistry published new progress about Antibacterial agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Synthetic Route of 5505-63-5.
Referemce:
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