Kaithal, Akash; van Bonn, Pit; Hoelscher, Markus; Leitner, Walter published the artcile< Manganese(I)-Catalyzed β-Methylation of Alcohols using Methanol as C1 Source>, Synthetic Route of 403-41-8, the main research area is manganese catalyzed methylation biomass alc methanol solvent safety; alcohols; hydrogen borrowing; manganese catalysis; methanol; methylation.
Highly selective β-methylation of alcs. was achieved using an earth-abundant first row transition metal in the air stable mol. manganese complex [Mn(CO)2Br[HN(C2H4PiPr2)2]] (I) ([HN(C2H4PiPr2)2]=MACHO-iPr). The reaction requires only low loadings of I (0.5 mol %), methanolate as base and MeOH as methylation reagent as well as solvent. Various alcs. were β-methylated with very good selectivity (>99%) and excellent yield (up to 94%). Biomass derived aliphatic alcs. and diols were also selectively methylated on the β-position, opening a pathway to “”biohybrid”” mols. constructed entirely from non-fossil carbon. Mechanistic studies indicate that the reaction proceeds through a borrowing hydrogen pathway involving metal-ligand cooperation at the Mn-pincer complex. This transformation provides a convenient, economical, and environmentally benign pathway for the selective C-C bond formation with potential applications for the preparation of advanced biofuels, fine chems., and biol. active mols. Of note, safety advice is recommended for high-pressure experiments due to significant risk with procedures and in conjunction with the use of suitable equipment.
Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (biomass). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts