N-Phosphorylated derivatives of 5-nitroindazole as antimicrobial and antioxidant agents and docking study against DNA gyrase A was written by Thaslim Basha, S. K.;Subba Rao, Devineni;Madhava, Golla;Basha, Shaik Thahir;Devamma, Mundla Nagalakshmi;Saddala, Madhu Sudhana;Asupatri, Usha Rani;Raju, Chamarthi Naga. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2015.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:
A series of new phosphoramidates I [R = (CH2)4N, O(CH2CH2)2N, (CH2)5N, etc.] were synthesized by reacting 5-nitroindazole with 4-chlorophenyl dichlorophosphate, and then further with various bio-potent aromatic/hetero/alkyl amines. All the newly synthesized compounds were characterized by spectroscopic data (IR, 1H, 13C, 31P NMR and mass) and elemental anal. The products were evaluated for their antioxidant activity (DPPH, H2O2 methods and IC50 values) and antimicrobial activity against the growth of Gram bacterial (pos. and neg.) and fungal pathogens. In the entire bio-screening data, the authors observed that is the most active compound in terms of its antimicrobial and antioxidant activities. Further to know the binding interactions of title products with DNA gyrase A enzyme (E. coli), mol. docking studies were performed which revealed and exhibited high binding affinities towards the enzyme, DNA gyrase A, and are higher than that of the standard antibiotic, streptomycin. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: (R)-2-Aminobutan-1-ol
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