Month: February 2023

Asymmetric Transfer Hydrogenation Catalyzed by Mesoporous MCM-41-Supported Chiral Ru-Complex was written by Sarkar, Shaheen M.;Yusoff, Mashitah Mohd.;Rahman, Lutfor Md.. And the article was included in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2015.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

Chiral N-sulfonyldiamine was successfully anchored on mesoporous MCM-41 silica. The MCM-41-supported chiral N-sulfonyldiamine was used as an efficient heterogeneous chiral ligand in the asym. transfer hydrogenation of ketones. This heterogeneous system offered satisfactory enantioselectivities up to 94% with excellent conversions. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Prototypes of nutraceutical products from microparticles loaded with stilbenes extracted from grape cane was written by Avendano-Godoy, Javier;Ortega, Elisa;Urrutia, Manuel;Escobar-Avello, Danilo;Luengo, Javiana;von Baer, Dietrich;Mardones, Claudia;Gomez-Gaete, Carolina. And the article was included in Food and Bioproducts Processing in 2022.Recommanded Product: 10083-24-6 This article mentions the following:

Grape canes (Vitis vinifera L.) are an important source of bioactive stilbenes, but they are considered a pruning residue. Despite the potential advantages for human health, the low aqueous solubility and stability limits their usage in com. goods. This research aimed to improve knowledge about the solubility and stability of the main stilbenes present in important residues of the wine industry, such as grape canes (V. vinifera L. cv Pinot Noir), through the formation of inclusion complexes with cyclodextrins (CDs) and subsequent polymeric microencapsulation. The formation of inclusion complexes between stilbenes presents in grape cane extracts and 15 mM hydroxypropyl-β-cyclodextrin (HP-β-CD) increased the aqueous solubility of (E)-resveratrol, (E)-ε-viniferin and (E)-piceatannol by 2.8, 5.4 and 1.9 times, resp. The microencapsulation (by spray drying) of the inclusion complexes using maltodextrin (MD) (10% w/v) allowed us to improve the stability of the stilbenes, obtaining a retention percentage of 81.9 ± 2.2% after 60 min of UV irradiation (254 nm). The lower size microparticles (MPs) formulation was 10.9 ± 0.9 μm and had a stilbene loading of 0.61 ± 0.01 mg/100 mg of MPs. The prototype tablets and capsules made from the MPs presented suitable characteristics for their eventual use. The microencapsulation of inclusion complexes between stilbenes presents in grape cane extracts and HP-β-CD, using MD as a matrix component, is useful to increase the solubility and stability of stilbenes. The prepared MPs can be used for the development of nutraceutical products. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemical Composition and Antioxidant Activities of the Essential oil of Olax acuminata was written by Chetia, Bolin;Phukan, Alakesh. And the article was included in Journal of Essential Oil-Bearing Plants in 2014.SDS of cas: 2451-01-6 This article mentions the following:

In the present study, chem. composition and antioxidant activities of the essential oil of Olax acuminata was investigated. The essential oils obtained by hydrodistillation was analyzed by gas chromatog.-mass spectrometry (GC-MS). α-Terpineol (11.5 %) was the major component of the essential oil of O. acuminata. Further the antioxidant activity of the essential oil of the leaves of the plant was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide radical scavenging assay. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6SDS of cas: 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and antiproliferative evaluation of some 1,4-naphthoquinone derivatives against human cervical cancer cells was written by Kacmaz, Aysecik;Deniz, Nahide Gulsah;Aydinli, Serdar Goksin;Sayil, Cigdem;Onay-Ucar, Evren;Mertoglu, Elif;Arda, Nazli. And the article was included in Open Chemistry in 2019.Reference of 29364-29-2 This article mentions the following:

In the course of biol. properties of quinone derivatives, the N(H)-, S- and S,S-substituted-1,4-naphthoquinones were synthesized by reactions of 2,3-dichloro-1,4-naphthoquinone with different amines (2-morpholinoaniline, tert-Bu 4-aminobenzoate, 4-tertbutylbenzylamine, N-(3-aminopropyl)-2-pipecoline, 2-amino-5,6-dimethylbenzothiazole, N,N’-diphenyl-p-phenylenediamine) and thiolate (sodium 2-methyl-2-propanethiolate). The antiproliferative activities of these compounds against human cervical cancer (HeLa) cells were evaluated by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay. Although all derivatives inhibited cell growth, the most active compound was 2-(tert-butylthio)-3-chloronaphthalene-1,4-dione (IC₅₀ = 10.16μM) against the HeLa cells. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Reference of 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Self-healing and printable elastomer with excellent shear stiffening and magnetorheological properties was written by Ding, Li;Zhang, Shuaishuai;Wang, Qi;Wang, Yu;Xuan, Shouhu;Gong, Xinglong;Zhang, Dongsheng. And the article was included in Composites Science and Technology in 2022.Recommanded Product: 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

This work reports a novel kind of hybrid magnetorheol. elastomer (HMRE) that possesses multi-functions including excellent shear stiffening and magnetorheol. (MR) effects, as well as self-healing and printable abilities. The HMRE materials are prepared by embedding carbonyl iron particles (CIPs) into a blend of silicon rubber (SR) and low crosslinking gel-like polyurethane (PU). The relative shear stiffening effect of HMRE-3:1 (the mass ratio of PU and SR is 3:1, and 50 weight% CIPs) is 6095% as the shear frequency increases from 0.1 Hz to 100 Hz, which is about 150 times that of SR based magnetorheol. elastomer (MRE). With the magnetic flux d. from 0 to 1T, MR effect of isotropic HMRE-3:1 is as high as 266%, which is 3.5 times that of SR based MRE. Notably, HMRE obtains extraordinary mech. and elec. healing capabilities. HMRE with a destructive cut-through injury can sustain an extensibility of 425% (the initial extensibility ∼650%) after healing. Meanwhile, possible mechanisms are proposed to explain the shear stiffening properties, MR effect, and self-healing performance of HMRE. Moreover, the extruded modeling 3D printing of flexible HMRE actuators can be achieved due to the plasticine property of pre-polymerized HMRE, which bestows HMRE with magnetic particle distribution programmability and shape designability. This work may provide a new way for the next-generation multifunctional materials with exceptional shear stiffening behavior, magnetically mech. properties, self-healabilities, and printable performance. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Recommanded Product: 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Catalytic Asymmetric Vinylogous Prins Cyclization: A Highly Diastereo- and Enantioselective Entry to Tetrahydrofurans was written by Xie, Youwei;Cheng, Gui-Juan;Lee, Sunggi;Kaib, Philip S. J.;Thiel, Walter;List, Benjamin. And the article was included in Journal of the American Chemical Society in 2016.Recommanded Product: (S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol This article mentions the following:

We describe the design and development of the first catalytic asym. vinylogous Prins cyclization. This reaction constitutes an efficient approach for highly diastereo- and enantioselective synthesis of tetrahydrofurans (THFs) and is catalyzed by a confined chiral imidodiphosphoric acid (IDP). Aromatic and heteroaromatic aldehydes react with various 3,5-dien-1-ols to afford 2,3-disubstituted THFs in excellent selectivity (d.r. > 20:1, e.r. up to 99:1). Aliphatic aldehydes react with similarly excellent results when a highly acidic imidodiphosphorimidate (IDPi) catalyst is used. With a racemic dienyl alc., the reaction proceeds via a kinetic resolution DFT calculations suggest an explanation for unusually high stereoselectivity. In the experiment, the researchers used many compounds, for example, (S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol (cas: 863659-89-6Recommanded Product: (S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol).

(S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol (cas: 863659-89-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: (S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of macrocyclic molecular rods as potential electronic devices was written by Blaszczyk, Alfred;Chadim, Martin;von Haenisch, Carsten;Mayor, Marcel. And the article was included in European Journal of Organic Chemistry in 2006.Application In Synthesis of Sodium 2-methyl-2-propanethiolate This article mentions the following:

The design and synthesis of the macrocycles I (R = H, NO₂) as model compounds for the investigation of neg. differential conductance phenomena in mol. junctions are reported. I (R = H, NO₂) comprise a mol. rod subunit consisting of three ethynyl-linked Ph rings. While the rotational freedom along the rod axis of both terminal Ph rings is limited by the macrocyclic frame, the central Ph ring is revolving. The rod substructure is terminally functionalized with acetyl-protected thiol groups to enable its immobilization between gold contacts. The central Ph ring is functionalized with one and two nitro groups for I (R = H, NO₂). The nitro groups are of particular importance as (i) both macrocycles are model compounds to investigate a hypothetical intramol. interaction of the nitro group with the opposite macrocyclic subunits and (ii) the nitro group(s) result in limited thermal stability of the compounds due to the intramol. rearrangement to macrocycles comprising isatogen subunits. These highly functionalized macrocycles have been assembled by acetylene scaffolding strategies in combination with functional group transformation chem. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Application In Synthesis of Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of dietary replacement of fish oil with soybean oil on the growth performance, plasma components, fatty acid composition and lipid metabolism of groupers Epinephelus coioides was written by He, Lingyun;Qin, Yingmei;Wang, Yanfei;Li, Dong;Chen, Weijun;Ye, Jidan. And the article was included in Aquaculture Nutrition in 2021.Recommanded Product: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

The aim of this study was to investigate the effects of substituting soybean oil (SO) for fish oil (FO) on the performance, tissue fatty acid (FA) composition, plasma components, liver metabolic enzyme activity and mRNA levels of genes related to lipid metabolism in the liver of groupers (Epinephelus coioides). We formulated five isolipidic and isoproteic diets with increasing SO levels (0, 250, 500, 750 and 1000 g/kg, resp.). Triplicate groups of 30 groupers (initial mean body weight of 12.6 g/fish) were fed one of the diets twice daily, to apparent satiety across a feeding period of 56 days. The growth performance, whole-body composition, and protein and lipid muscle contents did not differ across the dietary treatments. In contrast, the liver lipid content had pos. linear and quadratic responses to the increasing dietary SO levels, but the liver protein content had the opposite trend, and the highest lipid value and lowest protein value occurred in the 250 and 1000 g/kg SO diets, resp. There were no significant effects of increasing dietary SO inclusion levels on any of the plasma components and parameters of liver metabolic enzyme activity, except for acetyl CoA carboxylase and hepatic lipase, which showed linear and quadratic responses to increasing dietary SO inclusion levels and peaked at 1000 and 250 g/kg SO inclusion level, resp. However, the FA profiles of the dorsal muscle and liver generally reflected the FA profile of the diet. Furthermore, the mRNA levels of fas, acc, g6pd, lpl, pparα, cpt-1, srebp-1c, δ6fad and elovl5 in the liver exhibited pos. linear and/or quadratic responses to dietary SO inclusion levels. However, neg. linear and/or quadratic responses were observed for the mRNA levels of hsl and atgl in the liver, with increasing dietary SO inclusion levels. The mRNA levels of scd and fabp in the liver were not affected by the dietary SO inclusion level. These results indicate that FO could be replaced completely by SO without affecting growth. However, the inclusion of SO at levels higher than 500 g/kg could compromise the FA profile in the liver and flesh of the fish species. These results provide a novel insight into the potential utilization of SO in grouper feeds. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Recommanded Product: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

ansa-Ruthenium(II) Complexes of DPEN-SO₂N(Me)(CH₂)_n(η⁶-aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones was written by Kisic, Andrea;Stephan, Michel;Mohar, Barbara. And the article was included in Advanced Synthesis & Catalysis in 2014.Application of 171032-87-4 This article mentions the following:

A diversified ansa-ruthenium(II) catalyst series displaying enantiopure N,C-(N-alkylene-N-methylsulfamoyl)-tethered (DPEN-κ²N,N’)/η⁶-arene (DPEN = trans-1,2-diphenylethylenediamine) hybrid ligands was screened in the transfer hydrogenation of alkyl aryl ketones and α- or β-diketones in formic acid-triethylamine (HCO₂H-Et₃N) medium under mild conditions and furnished the alcs. in high to excellent ees. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Application of 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ospemifene plus fractional CO₂ laser: a powerful strategy to treat postmenopausal vulvar pain was written by Murina, F.;Felice, R.;Di Francesco, S.;Nelvastellio, L.;Cetin, I.. And the article was included in Gynecological Endocrinology in 2020.Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

This study is a single-center, retrospective anal. of postmenopausal women presenting with dyspareunia and vulvar pain, aiming to evaluate relative effectiveness of vestibular CO2 laser therapy as a treatment. Three monthly sessions of laser were performed to each patient and thereafter a three-months follow-up was stablished. A total number of 72 patients undergoing vestibular laser treatment were recruited from patient files in the period between 2016 and 2018. Among these, 39 women also received a concomitant treatment with ospemifene (60 mg/day) during the study period. There was a statistically significant reduction of all the symptoms in both groups up to the three month follow-up. Regarding dryness and dyspareunia, the relief tent to be more prominent in the ospemifene + laser group at all follow-ups and remained statistically significant at three-month follow-up. Specifically, vestibular dryness was significantly lower in the ospemifene + laser group compared with the laser treatment group (-87% vs – 34%, resp.), and the vestibular health score started declining faster in the ospemifene + laser group. Although, addnl. research is needed to understand the mechanism of action, our data shows that a combination regimen of laser and ospemifene may improve clin. effectiveness for long-term treatment of symptoms associated with the under-recognized genitourinary syndrome of menopause. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts