Month: February 2023

Solubility of terpin hydrate in hydroalcoholic solutions was written by Mascardo, Lydia B.;Barr, Martim. And the article was included in Journal of the American Pharmaceutical Association, Practical Pharmacy Edition in 1953.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

A table and figure shows the solubility of terpin hydrate in various hydroalcholic solutions making it possible to determine rapidly the percent of alc. required to dissolve a given amount of the compound In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

High-throughput profiling volatiles in edible oils by cooling assisted solid-phase microextraction technique for sensitive discrimination of edible oils adulteration was written by Xu, Shengrui;Li, Huimin;Dong, Panlong;Wang, Miaomiao;Chen, Chang-Po;Feng, Suling;Fan, Jing. And the article was included in Analytica Chimica Acta in 2022.Product Details of 3391-86-4 This article mentions the following:

In this study, a cooling assisted solid-phase microextraction technique (CA-SPME) was proposed and used for identifying volatile and semi-volatile compounds in edible oil innovatively coupled to gas chromatog.-mass spectrometry. Compared with regular SPME technique, CA-SPME presented significantly higher extraction efficiencies for analytes in edible oil due to its synergistic effect of heating and cooling. After optimization of the extraction conditions including heating temperature, cooling temperature, extraction time, and added amount of edible oil, thirty-eight, thirty-six, twenty-nine, and thirty-three kinds of compounds in peanut oil, olive oil, canola oil, and soybean oil were successfully identified, resp., using DVB/CAR/PDMS coating with extraction time of 30 min and edible oil amounts of 20 μL. Principal component anal., partial least squares discriminant anal., and hierarchical clustering anal. (HCA) were performed to evaluate the potential of proposed method in discriminating edible oils adulteration (peanut oil adulterated with canola oil, peanut oil adulterated with soybean oil, olive oil adulterated with canola oil) subsequently. Results demonstrated that the method was useful in successful discrimination of pure and adulterated edible oils with adulteration percentages ranging from 0.5 to 10%. Furthermore, volatiles contributing to classifications between pure and adulterated edible oils were also illustrated based on variable importance for the projection anal. and distributions of volatiles in HCA heatmaps. The proposed method provided a novel strategy for sensitive detection of edible oil adulteration without any other sample pretreatment. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Product Details of 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA-binding properties was written by Li, Zhen;Yan, Hui;Chang, Guoliang;Hong, Min;Dou, Jianmin;Niu, Meiju. And the article was included in Journal of Photochemistry and Photobiology, B: Biology in 2016.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:

A series of novel copper(II) and nickel(II) complexes derived from chiral Schiff-base ligands [(R)/(S)-H₂L¹ = (R)/(S)-2-[(1-Hydroxymethyl-propylimino)-methyl]-5-methoxy-phenol and (R)/(S)-H₂L² = (R)/(S)-2-[(1-Hydroxymethyl-2-phenyl-ethylimino)-methyl]-5-methoxy-phenol], were synthesized and characterized by elemental analyses, ¹H NMR spectra, FTIR spectrum. The crystal structures of 1–5 [Ni₂L₂(OAc)₂(solv)₂] were determined through single crystal x-ray diffraction (SXRD). The structures showed the ligands coordinated to the Cu/Ni(II) ion in a neutral manner via ONO donor atoms, and oxygen atoms of solvent mols. occupy the axial positions in Ni(II) complexes 3 and 4. The complexes interactions with BSA and CT-DNA were investigated by various spectroscopic methods (UV-Visible, CD spectrum, fluorescence spectroscopic and synchronous fluorescence spectra). Interactions of chiral copper(II) complexes are stronger than nickel(II) complexes. Further, the cytotoxicities of 1–6 towards three kinds of cancerous cell lines, were human lung adenocarcinoma (A549), human cervical carcinoma cell (HeLa) and human breast cancer cell (MCF-7), resp., were evaluated by MTT assay. All complexes exhibited good cytotoxic activity. Furthermore, Cu(II) complex 5 derived from (R)-Schiff-base ligand is more effective towards HeLa cancerous cell. Chirality and metal ion have important influence on their anticancer activities and interactions with DNA/BSA. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents was written by Houze, Sandrine;Hoang, Nha-Thu;Lozach, Olivier;Le Bras, Jacques;Meijer, Laurent;Galons, Herve;Demange, Luc. And the article was included in Molecules in 2014.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:

In Africa, malaria kills one child each minute. It is also responsible for about one million deaths worldwide each year. Plasmodium falciparum, is the protozoan responsible for the most lethal form of the disease, with resistance developing against the available anti-malarial drugs. Among newly proposed anti-malaria targets, are the P. falciparum cyclin-dependent kinases (PfCDKs). There are involved in different stages of the protozoan growth and development but share high sequence homol. with human cyclin-dependent kinases (CDKs). We previously reported the synthesis of CDKs inhibitors that are structurally-related to (R)-roscovitine, a 2,6,9-trisubstituted purine, and they showed activity against neuronal diseases and cancers. In this report, we describe the synthesis and the characterization of new CDK inhibitors, active in reducing the in vitro growth of P. falciparum (3D7 and 7G8 strains). Six compounds are more potent inhibitors than roscovitine, and three exhibited IC50 values close to 1 μM for both 3D7 and 7G8 strains. Although, such mols. do inhibit P. falciparum growth, they require further studies to improve their selectivity for PfCDKs. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iminophenyl Oxazolinylphenylamine for Enantioselective Cobalt-Catalyzed Hydrosilylation of Aryl Ketones was written by Chen, Xu;Lu, Zhan. And the article was included in Organic Letters in 2016.Product Details of 120121-01-9 This article mentions the following:

A family of chiral iminophenyl oxazolinylphenylamines (IPOPA) was designed and synthesized through three steps from com. available starting materials. An efficient cobalt-catalyzed asym. hydrosilylation of simple ketones with a low catalyst loading of CoCl₂ and IPOPA was developed to afford chiral alcs. in good yields with high enantioselectivities. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Product Details of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Product Details of 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Study on extraction process of root of henry wood betony polysaccharides and their antitumor activity against S180 was written by Feng, Haibo;Tian, Lan. And the article was included in Molecules in 2021.Electric Literature of C6H14O6 This article mentions the following:

We optimized the hot water extraction of polysaccharides from the root of Henry wood betony (RHWPs) using a uniform test and explored their anti-tumor activities in vitro and in vivo. The optimal extraction conditions were as follows: 40 min extraction time, liquid/solid ratio 30 mL/g, 100 min soaking time, two extraction cycles, 100% ethanol concentration, and extraction temperature of 80 degC. The mol. weight distribution of RHWPs with MWs was 228,600 g/mol and 5001 g/mol. The IR spectrum further indicated that RHWPs are acidic polysaccharides containing pyranose and furan rings. The main monosaccharides found in RHWPs were mannose, ribose, l-rhamnose monohydrate, glucuronic acid, galacturonic acid, glucose, galactose, xylose, arabinose, and fucose. RHWPs inhibited the proliferation of S180 tumor cells and induced apoptosis in vitro. Oral administration of RHWPs to tumor-bearing mice significantly inhibited the growth of the S180 xenografts, accelerated apoptosis in tumor cells, and expanded the necrotic regions. Furthermore, RHWPs also markedly increased the levels of TNF-alpha, IFN-gamma, and IL-2 in the sera of tumor-bearing mice, and activated immune cells such as lymphocytes, NK cells, and macrophages, thereby inducing tumor cell apoptosis. Taken together, RHWPs are a promising anti-tumor agent that ought to be explored further. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Electric Literature of C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of dietary protein substitution of fishmeal with black soldier fly larval meal on growth and physiological responses of juvenile striped catfish, Pangasianodon hypophthalmus was written by Sudha, Chandrasekaran;Ahilan, Baboonsundaram;Felix, Nathan;Uma, Arumugam;Prabu, Elangovan. And the article was included in Aquaculture Research in 2022.Name: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

A 10-wk feeding trial was conducted to determine the effects of dietary black soldier fly larval meal (BSFLM) on growth performances, digestive enzyme activity, haematol. responses and muscle growth-related gene expression of juvenile striped catfish (Pangasianodon hypophthalmus). Six isonitrogenous and isolipidic diets were formulated with BSFLM to replace fishmeal at 0 per cent (T0), 20 per cent (T20), 40 per cent (T40), 60 per cent (T60), 80 per cent (T80) and 100 per cent (T100). A total of 540 fingerlings were randomly distributed into 18 tanks and fed thrice a day. Growth performance and feed utilization of fish fed T20, T40 and T60 diets were not significantly different from T0 diet. However, increasing the percentage of fishmeal replacement with BSFLM to 100% at an inclusion level of 292 g/kg resulted in a substantial reduction in growth and feed efficiency of striped catfish. Fish fed T80 and T100 diets had significantly lower whole-body crude protein, crude lipid, total cholesterol and triglyceride value than fish fed other exptl. diets, while dietary inclusion of BSFLM had no significant effect on the whole-body amino acid profile, haematol. responses and intestinal and liver protease and amylase activity of striped catfish. However, lipase activity was increased in fish fed T80 and T100 diets. T80 and T100 hepatocytes were shown to have greater congestion in histol. than other groups. The relative expression of MyoD and myogenin was significantly maximized in fish fed the T60 diet. Fishmeal may be replaced with BSFLM up to 60 per cent at an inclusion level of 174 g/kg in the diet of juvenile striped catfish. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Name: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

2-Amino-6-(hydroxymethyl)pyridine was written by Goswami, Shyamaprosad;Dey, Swapan;Fun, Hoong Kun;Chantrapromma, Suchada. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2006.Application of 79651-64-2 This article mentions the following:

Crystals of the title compound are monoclinic, space group P2₁/c; Z = 4. The mol. is almost planar; the hydroxymethyl group deviates slightly from the plane of the ring. The mols. are linked into a chain running along the a-axis direction by an O-H…N H bond. N-H…O and N-H…N H bonds connect the chains, forming a mol. layer parallel to the (001) plane. A C-H…π interaction is also observed in the layer. In the experiment, the researchers used many compounds, for example, (6-Aminopyridin-2-yl)methanol (cas: 79651-64-2Application of 79651-64-2).

(6-Aminopyridin-2-yl)methanol (cas: 79651-64-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 79651-64-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asymmetric Transfer Hydrogenation of Aryl Ketones Catalyzed by Salt-Free Two Samarium Centers Supported by a Chiral Multidentate Alkoxy Ligand was written by Ohno, Kouji;Kataoka, Yasutaka;Mashima, Kazushi. And the article was included in Organic Letters in 2004.Product Details of 120121-01-9 This article mentions the following:

The authors synthesized a chiral multidentate ligand, (R,R,R,R)-N,N,N’,N’-tetra(2-hydroxy-2-phenylethyl)-1,3-xylylene diamine [(R)-I], which can support two metals at adjacent positions. Asym. transfer hydrogenation of acetophenone and its derivatives was conducted by using salt-free bimetallic lanthanoid complexes of (R)-I, and the combination of two samarium atoms and (R)-I was found to be the best catalyst system for asym. transfer hydrogenation of aryl ketones in high enantioselectivity (up to >99% ee). In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Product Details of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Diarylmethane synthesis through Re₂O₇-catalyzed bimolecular dehydrative Friedel-Crafts reactions was written by Qin, Qi;Xie, Youwei;Floreancig, Paul E.. And the article was included in Chemical Science in 2018.HPLC of Formula: 220227-37-2 This article mentions the following:

The application of Re₂O₇ for the synthesis of diarylmethanes from benzylic alcs. through solvolysis followed by Friedel-Crafts alkylation was described. The reactions were characterized by broad substrate scope, low catalyst loadings, high chem. yields and minimal waste generation. The intermediate perrhenate esters were superior leaving groups to chlorides and bromides in these reactions. The polarity and water sequestering capacity of hexafluoroisopropyl alc. were critical to the success of these processes. Re₂O₇ was a precatalyst for HOReO₃, which served as a less costly and easily handled promoter for these reactions. Oxorhenium catalysts selectively activate alcs. in the presence of similarly substituted acetates, indicating a unique chemoselectivity and mechanism in comparison to Bronsted acid catalysis. In the experiment, the researchers used many compounds, for example, (3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2HPLC of Formula: 220227-37-2).

(3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 220227-37-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts