Month: February 2023

Heterogeneous Catalysis for Oxidation of Alcohol via 1-Methyl-2-azaadamanane N-oxyl Immobilized on Magnetic Polystyrene Nanosphere was written by Guo, Xiaqun;Li, Meichao;Wang, Jianli;Li, Chunmei;Hu, Xinquan;Jin, Liqun;Sun, Nan;Hu, Baoxiang;Shen, Zhenlu. And the article was included in ChemistrySelect in 2022.SDS of cas: 873-76-7 This article mentions the following:

A highly promising heterogeneous strategy was describedn in which a catalytic amount of 1-methyl-2-azaadamanane N-oxyl immobilized on magnetic polystyrene nanosphere (1-Me-AZADO/MPNs) was used and a series of carbonyl compounds were obtained from various alcs. in 73-99% isolated yields and high selectivity (>99%) under Anelli conditions, thus offering a greener and more convenient methods in the synthesis of carbonyl compounds The attractive features of convenient magnetic separation (within seconds), good recyclability (up to 20 runs) and fast reaction rates (5-20 min) were very efficient to improve the utility of azaadamantane-type-nitroxyl radicals in the oxygenation. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7SDS of cas: 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists was written by Galley, Guido;Beurier, Angelica;Decoret, Guillaume;Goergler, Annick;Hutter, Roman;Mohr, Susanne;Pahler, Axel;Schmid, Philipp;Turck, Dietrich;Unger, Robert;Zbinden, Katrin Groebke;Hoener, Marius C.;Norcross, Roger D.. And the article was included in ACS Medicinal Chemistry Letters in 2016.Related Products of 926291-77-2 This article mentions the following:

2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting from a known adrenergic compound, structural modifications were made to obtain highly potent and selective TAAR1 ligands such as (I) (RO5166017), (II) (RO5256390), RO5203648, and RO5263397. These compounds exhibit drug-like physicochem. properties, have good oral bioavailability, and display in vivo activity in a variety of animal models relevant for psychiatric diseases and addiction. In the experiment, the researchers used many compounds, for example, (R)-2-Amino-2-(3-chlorophenyl)ethanol (cas: 926291-77-2Related Products of 926291-77-2).

(R)-2-Amino-2-(3-chlorophenyl)ethanol (cas: 926291-77-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 926291-77-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dependence of the antimicrobial activity of chemical preservatives in suspensions on several pharmaceutical factors was written by Pertsev, I. M.;Khokhlova, L. N.;Dmitrievskii, D. I.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1984.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

The adsorption of chem. preservatives such as nipagin  [99-76-3], nipazol  [94-13-3], sorbic acid  [110-44-1], benzoic acid  [65-85-0], benzalkonium chlorides and ethonium  [21954-74-5] by solid phase drug-suspensions was studied. The suspensions contained Al₂O₃, BaSO₄, Ca glycerophosphate [27214-00-2], MgCO₃, MgO, menthol  [1490-04-6], talc, terpin hydrate  [2451-01-6], phenyl salicylate  [118-55-8] and phthalazole  [85-73-4] in 1, 2.5 and 5% concentrations The quantity of the adsorbed preservatives increased with the concentration of solid phases up to 2.5% drug concentration Since nipagin and nipazole showed the least adsorption, a combination of these was chosen for preserving the suspensions and their concentration increased to study their adsorption. Since benzoic acid and sorbic acid adsorbed most of the drugs used they should not be used as preservatives. In addition, the effect of stabilizers, Tween 80  [9005-65-6] Me cellulose  [9004-67-5], and gelatose  [52624-15-4] on the adsorption of the preservatives were studied. Tween 80 increased the adsorption degree of all the preservatives studied, gelatose decreased it and Me cellulose also increased the degree of adsorption of all the preservatives except that of sorbic acid. The antimicrobial activity was decreased when the stabilizers were not used, especially with sorbic acid. The stabilizers in general increased the antimicrobial activity. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of 1,3-Dicarbonyl Compounds using N-Cbz Amides as an Acyl Source under Transition-metal-free Conditions at Room Temperature was written by Singh, Shweta;Kandasamy, Jeyakumar. And the article was included in Asian Journal of Organic Chemistry in 2022.Synthetic Route of C10H20O This article mentions the following:

A wide range of functionalized N-Cbz amides underwent base-promoted C-C coupling reactions with enolizable esters, ketones and amides to afford 1,3-dicarbonyl compounds under mild conditions. The reactions proceeded at room temperature in the presence of LiHMDS in cyclopentyl Me ether (CPME). The desired β-ketoesters, β-keto amides and 1,3-diketones were obtained in good to excellent yields in a short reaction time. Broad substrate scope, functional group tolerance and metal-free conditions are the merits of the developed methodol. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Synthetic Route of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Redox-Induced Single-Molecule Magnetism in Mixed-Valent [2 × 2] Co₄ Grid Complexes was written by Tong, Jin;Demeshko, Serhiy;John, Michael;Dechert, Sebastian;Meyer, Franc. And the article was included in Inorganic Chemistry in 2016.Recommanded Product: 49669-14-9 This article mentions the following:

Homovalent [2 × 2] Co₄ grid complexes [Co^II₄L^H₄](BF₄)₄ (1) and [Co^II₄L^Me₄](BF₄)₄ (2) with two new bis(terdentate) pyrazolate-bridged ligands, HL^H = 3,5-bis(6-(1H-pyrazol-1-yl)pyrid-2-yl)pyrazole and HL^Me = 4-methyl-3,5-bis(6-(1H-pyrazol-1-yl)pyrid-2-yl)pyrazole, were synthesized and comprehensively characterized. X-ray crystallog. analyses of 1 and 2 showed a square arrangement of cobalt(II) ions, each metal ion in distorted octahedral {N₆} coordination created by two terdentate compartments from orthogonal ligand strands. Magnetic measurements revealed the metal ions’ high-spin (S = 3/2) state and moderate antiferromagnetic interactions to give an overall diamagnetic S_T = 0 ground state of 1 and 2. Twofold oxidation, electrochem. or chem., led to the dimixed-valent [2 × 2] Co₄ grids [Co^II₂Co^III₂L^H₄](BF₄)₆ (3) and [Co^II₂Co^III₂L^Me₄](BF₄)₆ (4). ESI mass spectrometry confirmed the ruggedness of all grids 1-4 and their integrity in solution, and anal. of the UV/vis/NIR spectra suggested moderate electronic coupling. Solution ¹H and ¹³C NMR spectra of paramagnetic 1-4 were recorded and confirmed that the dimixed-valent Co^II₂Co^III₂ grids are charge-localized on the NMR time scale. X-ray crystallog. revealed significant structural grid distortion upon oxidation, with the low-spin Co^III at opposite corners and in almost octahedral {N₆} environment but the remaining Co^II ions’ coordination sphere approaching a trigonal prism. SQUID studies showed the high-spin Co^II to be magnetically isolated in the dimixed-valent Co^II₂Co^III₂ grids, and both 3 and 4 to display frequency-dependent peaks in the out-of-phase (χ”) component of the alternating-current (ac) magnetic susceptibility data, characteristic for single mol. magnet (SMM) properties (with energy barriers U_eff/k_B = 16 and 26 K, and relaxation times τ₀ = 6.7·10^-6 and 5.0·10^-6 s for 3 and 4, resp.). The results are discussed in terms of cooperative effects that originate from elastic coupling within the grids, mediated by the rigid bridging ligands. These effects synergistically lead to the preferred trans configuration of the dimixed-valent Co^II₂Co^III₂ grids and to structural distortions that are beneficial for SMM properties. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9Recommanded Product: 49669-14-9).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 49669-14-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Development of Water-Soluble Type I Photoinitiators for Hydrogel Synthesis was written by Aubry, Berengere;Dumur, Frederic;Lansalot, Muriel;Bourgeat-Lami, Elodie;Lacote, Emmanuel;Lalevee, Jacques. And the article was included in Macromol in 2022.Safety of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

In this work, two new water-soluble photoinitiators based on the α-alkoxy-arylketone scaffold have been synthesized and investigated for their ability to initiate photopolymerization for the preparation of hydrogels. The efficiency of these new Type I photoinitiators was compared to that of benchmark ones (2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone-Irgacure 2959 and 2-hydroxy-2-Me propiophenone-Irgacure 1173). In combination with additive (carbene-borane), a good initiating ability was found under air. Mech. properties of the prepared hydrogels were investigated by tensile tests and dynamic mech. anal. (DMA). Markedly, hydrogels could be prepared with the newly proposed initiating systems in mild conditions (i.e., under air, using low light intensity @405 or 395 nm and without specialized glassware) and exhibited similar properties to those prepared by harsher approaches (thermal treatment or UV light). In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Safety of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A novel approach for the preparation of core-shell MOF/polymer composites as mixed-mode stationary phase was written by Si, Tiantian;Wang, Licheng;Zhang, Haixia;Liang, Xiaojing;Lu, Xiaofeng;Wang, Shuai;Guo, Yong. And the article was included in Talanta in 2021.Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate This article mentions the following:

The nickel organic framework capped with polyvinylpyrrolidone was prepared and synergistically immobilized onto porous silica surface as the mixed-mode stationary phase for high-performance liquid chromatog. Here, polyvinylpyrrolidone firstly was chosen as functional mols. to change morphol. and size of the metal organic framework. The silica microspheres were then modified by them via a simple bonding method rather than in-situ growth method with the aid of electrostatic interaction commonly used before. The stationary phase showed flexible selectivity for separation of both hydrophilic and hydrophobic compounds, especially for hydrophilic compounds such as carbohydrates, alkaloids and sulfonamides etc. The chromatog. behaviors were evaluated by investigating various factors, and a typical mixed-mode retention feature of the column was observed The composites could be prepared repetitively, and relative standard deviations of retention time of objective compounds among different batches were less than 1.75%. It also showed excellent chromatog. reproducibility, stability and potentiality for application in real samples. In short, the composites can be used for a feasible option for anal. of multiple compounds as the mixed-mode stationary phase and it provides a general approach for preparing MOFs-based composites by changing morphol. and size of MOFs. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A simple and efficient room temperature silylation of diverse functional groups with hexamethyldisilazane using CeO₂ nanoparticles as solid catalysts was written by Anbu, Nagaraj;Vijayan, Chellappa;Dhakshinamoorthy, Amarajothi. And the article was included in Molecular Catalysis in 2019.Reference of 1777-82-8 This article mentions the following:

In this study, a mild and efficient method is developed for the silylation of diverse functional groups using CeO₂ nanoparticles (n-CeO₂) as solid catalysts with hexamethyldisilazane (HMDS) as silylating agent at room temperature Alcs., phenols and acids are silylated to their resp. silyl derivatives with faster reaction rate while amines and thiols required relatively longer reaction time. Moreover, the solid catalyst is easily be separated from the reaction mixture and recycled more than five times without any noticeable decay in its activity. Powder X-ray diffraction (XRD), transmission electron microscope (TEM), UV-vis diffuse reflectance spectra (UV-DRS) and Raman analyses revealed identical structural integrity, particle size, absorption edge and valence state for the reused solid compared to the fresh solid catalyst. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Reference of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The Bark of the Spruce Picea jezoensis Is a Rich Source of Stilbenes was written by Suprun, Andrey R.;Dubrovina, Alexandra S.;Aleynova, Olga A.;Kiselev, Konstantin V.. And the article was included in Metabolites in 2021.Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Stilbenes are plant phenolic secondary metabolites that show beneficial effects on human health and possess high antifungal activity against plant pathogens. Currently, a search for plant sources with high stilbene levels is relevant, since stilbene content in various plant species can vary substantially and is often at a low level. In this paper, the bark and wood of Picea jezoensis were analyzed for the content and composition of stilbenes and compared with other known stilbene sources. The HPLC-MS anal. of P. jezoensis bark and wood extracted with different solvents and at different temperatures revealed the presence of 11 and 5 stilbenes, resp. The highest number of stilbenes of 171 and 229 mg per g of the dry weight (mg/g DW) was extracted from the bark of P. jezoensis using methanol or ethanol at 60 °C for 2 h. Trans-astringin, trans-piceid, and trans-isorhapontin prevailed over other stilbenoids (99% of all detected stilbenes). The most abundant stilbene was trans-isorhapontin, reaching 217 mg/g DW or 87% of all stilbenes. An increase in the extraction time from 2 to 6 h did not considerably increase the detected level of stilbenes, while lower extraction temperatures (20 and 40 °C) significantly lowered stilbene yield. The content of stilbenes in the P. jezoensis bark considerably exceeded stilbene levels in other stilbene-producing plant species. The present data revealed that the bark of P. jezoensis is a rich source of stilbenes (primarily trans-isorhapontin) and provided effective stilbene extraction procedures. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of ospemifene on the female reproductive and urinary tracts: translation from preclinical models into clinical evidence. was written by Archer, David F;Carr, Bruce R;Pinkerton, JoAnn V;Taylor, Hugh S;Constantine, Ginger D. And the article was included in Menopause (New York, N.Y.) in 2015.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

OBJECTIVE: Treatment of menopausal symptoms by compounds with tissue-selective estrogen agonist/antagonist effects, often called selective estrogen receptor modulators, has been researched as an alternative to the use of estrogen therapy. These structurally diverse molecules elicit tissue-dependent responses in hormone-responsive tissues and organs, exhibiting variations in estrogenic activity in preclinical models of postmenopausal reproductive tissues that may improve postmenopausal women’s health (eg, prevention and treatment of breast cancer, osteoporosis, and vulvar and vaginal atrophy). METHODS: This literature review investigates whether preclinical data predicted the clinical effects of ospemifene on female reproductive and urinary tract tissues and compares these findings with the specific vaginal effects of other estrogen receptor agonists/antagonists (tamoxifen, raloxifene, and bazedoxifene) in preclinical and clinical studies. Lasofoxifene, although not currently available, is included because of its unique effects on vaginal tissue. RESULTS: The response of endometrial and vaginal tissues to estrogen receptor agonists/antagonists can be differentiated using transvaginal ultrasound, endometrial histopathology, cytologic examination of vaginal smears, assessment of physical changes in the vagina, and relief of symptoms associated with vulvar and vaginal atrophy (such as dyspareunia). CONCLUSIONS: Available evidence indicates that ospemifene has unique effects on tissue, leading to a favorable long-term profile for the relief of vulvar and vaginal atrophy compared with other estrogen receptor agonists/antagonists (eg, tamoxifen, raloxifene, and bazedoxifene) with no short-term concerns about endometrial safety (based on endometrial hyperplasia, carcinoma, endometrial spotting, and endometrial bleeding). In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts