Month: February 2023

One-pot synthesis of pompon-like magnetic hollow SiO₂-supported Ag nanoparticles for catalytic application was written by Li, Zhuo-Rui;Jiang, Bo;Zhang, Xiao-Hui;Han, Guo-Zhi. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Application In Synthesis of 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

In this paper, we develop a novel pompon-like magnetic hollow SiO₂-supported Ag (SiO₂@Ag) nanoparticles, in which small silver and magnetic nanoparticles were loaded on the hollow silica shell by one-pot solvothermal method. FT-IR, XRD, SEM, TEM and BET were applied to characterized the structure and morphol. of the magnetic hollow SiO₂@Ag nanoparticles. The synthesized material has not only high stability and monodispersity, but also uniform surface element distribution along with good magnetic response. On this basis, we studied the catalytic performance of this pompon-like magnetic hollow SiO₂@Ag nanoparticles for the reduction of aromatic nitro compounds, and further carried out extended researches on substrates scope. Research results indicate that the pompon-like magnetic hollow SiO₂@Ag nanoparticles have broad-spectrum catalytic activity for the reduction of aromatic nitro compounds After recycling for 8 times, it can still maintain 90% catalytic efficiency. This study provides a facile strategy for constructing hollow hierarchical structure, and expands the application of noble metal nanoparticles in organic transformation. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly enantioselective transfer hydrogenation of aromatic ketones was written by Pan, En-De;Li, Yan-Yun;Dong, Zhen-Rong;Chen, Jian-Shan;Li, Bao-Zhu;Zhang, Hui;Gao, Jing-Xing. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2003.Quality Control of (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

Enantioselective reduction of prochiral ketones with 2-propanol or formic acid catalyzed by chiral metal complexes has been developed as a synthetic method complementary to asym. hydrogenation in the past decade. However, these processes are necessary to be improved for practical use in organic synthesis because of low catalytic activity and insufficient enantioselectivity. In this paper, we report an excellent catalytic system generated in situ from iridium complex IrCl(Ph₃P)₃ and chiral tetradentate diaminodiphosphine ligand for asym. transfer hydrogenation of various aromatic ketones. For isobutyrophenone transfer hydrogenation, the corresponding optically active alc. was obtained in 93% yield and with up to 99% e. e. after 5 h at 28 °C. Propiophenone was a better substrate with respect to catalytic activity and enantioselectivity in the presence of base as a co-catalyst. The conversion of propiophenone reached 95.8% and the turnover number as high as 3 193 h^-1. These results will provide a useful index for further designing practical chiral catalytic systems. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Quality Control of (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carbon (1s) NEXAFS spectroscopy of biogeochemically relevant reference organic compounds was written by Solomon, Dawit;Lehmann, Johannes;Kinyangi, James;Liang, Biqing;Heymann, Karen;Dathe, Lena;Hanley, Kelly;Wirick, Sue;Jacobsen, Chris. And the article was included in Soil Science Society of America Journal in 2009.Formula: C6H14O6 This article mentions the following:

Natural organic matter (NOM) is a highly active component of soils and sediments, and plays an important role in global C cycling. However, NOM has defied mol.-level structural characterization, owing to variations along the decomposition continuum and its existence as highly functionalized polyelectrolytes. We conducted a comprehensive systematic overview of spectral signatures and peak positions of major organic mols. that occur as part of NOM using near-edge x-ray absorption fine structure (NEXAFS) spectroscopy. The spectra of carbohydrates and amino sugars show resonances between 289.10 and 289.59 eV, attributed to 1s-3p/σ* transitions of O-alkyl (C-OH) moieties. They also exhibited distinct peaks between 288.42 and 288.74 eV, representing C1s-π*_C=O transition from COOH functionalities. Amino acids produced a strong signal around 288.70 eV, which can be identified as a C 1s-π*_C=O transition of carboxyl/carbonyl (COOH/COO-) structures. Spectral features near 285.29 eV were ascribed to C 1s-π*_C=C transition of ring structure of aromatic amino acids, while spectra between 287.14 and 287.86 eV were attributed to C 1s-π*_C-H and C 1s-σ*_C-H/3p Rydberg-like excitations from CH and CH₂ groups. Phenols and benzoquinone produced strong resonances between 285.08 and 285.37 eV, attributed to the π* orbital of C (C 1s-π*_C=C) atoms connected to either C or H (C-H) in the aromatic ring. The next higher excitation common to both phenols and quinone appeared between 286.05 and 286.35 eV, and could be associated with C 1s-π*_C=C transitions of aromatic C bonded to O atom in phenols, and to C 1s-π*_C=O transitions from aromatic C connected to O atom (C-OH) in phenols or to a C=O in p-benzoquinone and some phenols with carbonyl structures, resp. Nucleobases exhibited complex spectral features with pronounced resonances between 286.02 and 286.84 eV and between 288.01 and 288.70 eV. Mol. markers for black C (benzenecarboxylic acid and biphenyl-4,4′-dicarboxylic acid) exhibit sharp absorption bands between 285.01 and at 285.43 eV, possibly from C 1s-π*_C=C transition characteristic of C-H sites or unsaturated C (C=C) on aromatic ring structures. These aromatic carboxylic acids also exhibit broad peaks between 288.35 and 288.48 eV, reflecting C 1s-π*_C=O transition of carboxyl functional groups bonded to unsaturated C. This investigation provides a more comprehensive NEXAFS spectral library of biogeochem. relevant organic C compounds The spectra of these reference organic compounds reveal distinct spectral features and peak positions at the C K-edge that are characteristic of the MOs bonding C atoms. Detailed structural information can be derived from these distinctive spectral features that could be used to build robust peak assignment criteria to exploit the chem. sensitivity of NEXAFS spectroscopy for in situ mol.-level spatial investigation and fingerprinting of complex organic C compounds in environmental samples. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Formula: C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of new mono-N-tosylated diamine ligands based on (R)-(+)-limonene and their application in asymmetric transfer hydrogenation of ketones and imines was written by Roszkowski, Piotr;Maurin, Jan K.;Czarnocki, Zbigniew. And the article was included in Tetrahedron: Asymmetry in 2013.HPLC of Formula: 120121-01-9 This article mentions the following:

A synthetic procedure leading to the preparation of a new family of enantiopure mono-N-tosylated-1,2-diamines derived from (R)-(+)-limonene is described. (+)-Limonene was transformed into the appropriate N-tosyl derivative using N-tosylaziridination based on chloramine-T trihydrate. Subsequent ring opening by sodium azide afforded the corresponding isomeric azides. Finally, reduction of the azide function gave enantiomerically pure mono-N-tosylated-1,2-diamines. The ligands obtained proved to be effective in the asym. transfer hydrogenation protocol on aromatic ketones and imines. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9HPLC of Formula: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship was written by Vianello, Paola;Sartori, Luca;Amigoni, Federica;Cappa, Anna;Faga, Giovanni;Fattori, Raimondo;Legnaghi, Elena;Ciossani, Giuseppe;Mattevi, Andrea;Meroni, Giuseppe;Moretti, Loris;Cecatiello, Valentina;Pasqualato, Sebastiano;Romussi, Alessia;Thaler, Florian;Trifiro, Paolo;Villa, Manuela;Botrugno, Oronza A.;Dessanti, Paola;Minucci, Saverio;Vultaggio, Stefania;Zagarri, Elisa;Varasi, Mario;Mercurio, Ciro. And the article was included in Journal of Medicinal Chemistry in 2017.Reference of 142253-56-3 This article mentions the following:

The balance of methylation levels at histone H3 lysine 4 (H3K4) is regulated by KDM1A (LSD1). KDM1A is overexpressed in several tumor types, thus representing an emerging target for the development of novel cancer therapeutics. The authors have previously described the identification of thieno[3,2-b]pyrrole-5-carboxamides, as novel reversible inhibitors of KDM1A, whose preliminary exploration resulted in compound (I) with biochem. IC₅₀ = 160 nM. The authors now report the structure-guided optimization of this chem. series, based on multiple ligand/KDM1A-CoRest co-crystal structures, which led to several extremely potent inhibitors. In particular, compounds N-[3-(methoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]- methoxy]phenoxy]methyl]phenyl]-4-methyl-thieno[3,2-b]-pyrrole-5-carboxamide hydrochloride (46), 4-ethyl-N-[3-(methoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]-methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide (49) and N-[3-(ethoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]-phenoxy]methyl]phenyl]-4-methyl-thieno[3,2-b]pyrrole-5-carboxamide hydrochloride (50) showed single digit nanomolar IC₅₀ values for in vitro inhibition of KDM1A, with high selectivity in secondary assays. In THP-1 cells these compounds transcriptionally affected the expression of genes regulated by KDM1A, such as CD14, CD11b, and CD86. Moreover, 49 and 50 showed a remarkable anti-clonogenic cell growth effect on MLL-AF9 human leukemia cells. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3Reference of 142253-56-3).

1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 142253-56-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of Ospemifene on Breast Tissue Morphology and Proliferation: A Comparative Study Versus Other Selective Estrogen Receptor Modulators in Ovariectomized Rats was written by Kangas, L.;Harkonen, P.;Vaananen, K.;Keskitalo, J.;Eigeliene, N.. And the article was included in Hormone and Metabolic Research in 2014.Application of 128607-22-7 This article mentions the following:

Ospemifene is a tissue-selective estrogen agonist/antagonist that was recently approved for the treatment of dyspareunia associated with vulvar and vaginal atrophy, which occurs in up to approx. 50% of postmenopausal women. The current analyses were conducted to determine whether ospemifene exhibits estrogenic activity in the mammary glands of ovariectomized rats and to compare potential estrogenic activity with selective estrogen receptor modulators (tamoxifen, raloxifene, and toremifene). Three sep. studies with differing durations (6, 9, and 28 days) were conducted using similar procedures in ovariectomized Sprague-Dawley rats. Estradiol treatment and sham-treated ovariectomized rats were used as pos. and neg. controls, resp. Cell proliferation was examined using labeled 5-bromo-2-deoxyuridine; cytoplasmic prolactin was characterized with antibody staining. The morphol. of the mammary gland was studied by histol. staining of sections from the right fourth mammary glands, and the excised gland from the left side was used for counting the lobulus number Neither ospemifene nor selective estrogen receptor modulators substantially induced 5-bromo-2-deoxyuridine staining, altered the morphol. of the mammary glands, or changed prolactin immunostaining in ovariectomized rats compared with the ovariectomized controls. With the exception of toremifene, the selective estrogen receptor modulators did not cause a substantial induction in mammary gland lobuli. Estradiol had effects opposite to those of the selective estrogen receptor modulators in these studies. Ospemifene exhibited no substantial estrogenic activity in the mammary gland of ovariectomized rats. Activity in the mammary gland of ovariectomized rats with ospemifene was comparable to raloxifene and tamoxifen. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Application of 128607-22-7).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 128607-22-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asymmetric Reductive Dicarbofunctionalization of Alkenes via Nickel Catalysis was written by Anthony, David;Diao, Tianning. And the article was included in Synlett in 2020.Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

A summary of the efforts to control enantioselectivity for alkene RCH=CH₂ [R = Ph, 4-(acetyloxy)benzen-1-yl, 1-[(4-methylbenzene)sulfonyl]-1H-indol-5-yl, etc.] and 1H-indene diarylation with a nickel catalyst was presented. This reaction is useful for preparing triarylethanes (1S/1R)-RCH(R¹)CH₂R¹ (R¹ = Ph, 4-chlorophenyl, 2H-1,3-benzodioxol-5-yl, etc.) and (1R,2R/1S,2S)-I. The selectivity is enhanced by an N-oxyl radical additive. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bis(μ-oxo)-Dititanium(IV)-Chiral Binaphthyldisulfonate Complexes for Highly Enantioselective Intramolecular Hydroalkoxylation of Nonactivated Alkenes was written by Xie, Wen-Bin;Li, Zhi. And the article was included in ACS Catalysis in 2021.Application In Synthesis of Sodium 2-methyl-2-propanethiolate This article mentions the following:

A series of chiral 1,1′-binaphthyl-2,2′-disulfonic acids was designed, synthesized, and applied in a highly enantioselective Ti-catalyzed intramol. hydroalkoxylation of nonactivated alkenes. The catalyst is probably a complex between two chiral binaphthyldisulfonate ligands and a bis(μ-oxo)-dititanium(IV) core structure. The sulfonamide groups of the ligands and water are necessary for the catalysis, as they may stabilize the catalytically active complex through hydrogen bonding. Various 2-methylcoumarans were obtained in up to greater than 99% yields and up to 97% enantiomeric excess under mild conditions. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Application In Synthesis of Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sustainable oxidation of olefins and sulfides employing nanopolyoxomolybdate supported by ionic liquid on dendritic fibrous nanosilica was written by Xiao, BoAn;Sadeghzadeh, Seyed Mohsen. And the article was included in Journal of Molecular Liquids in 2022.Recommanded Product: 3391-86-4 This article mentions the following:

Here, we reported a green and economical method for the oxidation of sulfides to sulfones and sulfoxides in water, and epoxidation of olefins in ethanol with O₂ in the presence of keplerate nanosized polyoxomolybdate [Mo₃₆₈] supported by ionic liquid between DFNS. In order to prepare the catalyst as a substrate to support [Mo₃₆₈] NPs, an ionic liquid was employed to activate the DFNS exterior level. Ionic liquid removed the requirement for a reducing agent and performed as a natural reducing and stabilizing agent for [Mo₃₆₈] NPs. The reaction efficiencies and selectivity were influenced by catalyst concentration A different structural series of olefins and sulfides was set into intended oxidation products in spite of the electronic essence of the substituents. Despite the presence of heterogeneous reaction blends, no problems were noted with reaction progress. Products were easily removed from the green medium, and the catalyst was employed various times without remarkable reduction in performance and selectivity. The results of UV-vis, Raman spectral data, TGA, FT-IR, XRD, TEM, and FESEM showed the involvement of a Mo(VI) peroxo complex in oxidation reactions. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Recommanded Product: 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molecular properties of bare and microhydrated vitamin B5-calcium complexes was written by Corinti, Davide;Chiavarino, Barbara;Scuderi, Debora;Fraschetti, Caterina;Filippi, Antonello;Fornarini, Simonetta;Crestoni, Maria Elisa. And the article was included in International Journal of Molecular Sciences in 2021.Related Products of 137-08-6 This article mentions the following:

Pantothenic acid, also called vitamin B5, is an essential nutrient involved in several metabolic pathways. It shows a characteristic preference for interacting with Ca(II) ions, which are abundant in the extracellular media and act as secondary mediators in the activation of numerous biol. functions. The bare deprotonated form of pantothenic acid, [panto-H]^–, its complex with Ca(II) ion, [Ca(panto-H)]⁺, and singly charged micro-hydrated calcium pantothenate [Ca(panto-H)(H2O)]⁺ adduct have been obtained in the gas phase by electrospray ionization and assayed by mass spectrometry and IR multiple photon dissociation spectroscopy in the fingerprint spectral range. Quantum chem. calculations at the B3LYP(-D3) and MP2 levels of theory were performed to simulate geometries, thermochem. data, and linear absorption spectra of low-lying isomers, allowing us to assign the exptl. absorptions to particular structural motifs. Pantothenate was found to exist in the gas phase as a single isomeric form showing deprotonation on the carboxylic moiety. On the contrary, free and monohydrated calcium complexes of deprotonated pantothenic acid both present at least two isomers participating in the gas-phase population, sharing the deprotonation of pantothenate on the carboxylic group and either a fourfold or fivefold coordination with calcium, thus justifying the strong affinity of pantothenate for the metal. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Related Products of 137-08-6).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 137-08-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts