Month: February 2023

Visible-Light-Promoted Desulfurative Alkylation of Alkyl Thianthrenium Salts with Activated Olefins was written by Li, Xin;Si, Weili;Liu, Zhanhui;Qian, Haitao;Wang, Tingxue;Leng, Shengnan;Sun, Jinwei;Jiao, Yan;Zhang, Xuan. And the article was included in Organic Letters in 2022.Computed Properties of C24H23ClO2 This article mentions the following:

Reactions involving an alkyl radical generated from a primary alc. by photochem. are rare and challenging. Herein, authors present a photocatalyst- and metal-free approach that enables the generation of an alkyl radical from the corresponding alc. and the subsequent C(sp³)-C(sp³) bond formation with activated olefin, via an alkyl thianthrenium salt/Hantzsch ester electron donor-acceptor complex. This protocol for the conversion of a C-OH bond to a C-C bond is highly functionality tolerant and can successfully be used in late-stage functionalization of pharmaceuticals. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Computed Properties of C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Computed Properties of C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enhanced mechanical and thermal properties of stereolithography 3D printed structures by the effects of incorporated controllably annealed anatase TiO₂ nanoparticles was written by Mubarak, Suhail;Dhamodharan, Duraisami;Divakaran, Nidhin;Kale, Manoj B.;Senthil, T.;Wu, Lixin;Wang, Jianlei. And the article was included in Nanomaterials in 2020.Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

Fabrication of low-cost, durable and efficient metal oxide nanocomposites were successfully synthesized and reinforced with photo-resin via 3-dimensional printing. Here, we put forward a novel approach to enhance the mech. and thermal behaviors of stereolithog. (SLA) 3D printed architecture by adding TiO₂ nanoparticles (TNPs) in different crystalline phases (anatase and rutile), which were obtained at different annealing temperatures from 400°C to 1000°C. The heat-treated anatase TNPs were scrutinized by X-ray diffraction, XPS, Raman spectroscopy, diffusive reflectance spectroscopy, and transmission electron microscopy anal. Among all the samples, at 800°C, annealed anatase TNPs exposed a highly crystalline anatase phase, having a low energy band gap and a comparably high tensile strength (47.43 MPa) and high elastic modulus (2.261 GPa) for the 3D printed samples, showing improvement by 103% and 32%, resp., compared with the printed pristine stereolithog. resin (SLR) sample. Moreover, enhanced storage modulus and tan δ values were achieved via the better interfacial interactions between the incorporated nanofillers and the SLR matrix. In addition to this, enhanced thermal conductivity and thermal stability of the SLR matrix were also noted. The low energy bandgap and nanoscale size of the fillers helped to achieve good dispersion and allowed the UV light to penetrate at a maximum depth through the photo resin. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gallium oxide thin films from the AACVD of [Ga(NMe₂)₃]₂ and donor functionalised alcohols was written by Basharat, Siama;Carmalt, Claire J.;Binions, Russell;Palgrave, Robert;Parkin, Ivan P.. And the article was included in Dalton Transactions in 2008.Category: alcohols-buliding-blocks This article mentions the following:

Thin films of Ga₂O₃ were produced from [Ga(NMe₂)₃]₂ and ROH (R = CH₂CH₂NMe₂, CH(CH₂NMe₂)₂, CHMeCH₂NMe₂, CH₂CH₂OMe and CMe₂CH₂OMe) by aerosol assisted CVD on glass. Transparent, unreflective films were obtained at a deposition temperature of 550° using toluene as solvent. The Ga oxide films were analyzed by SEM, Raman spectroscopy, wavelength dispersive anal. of x-rays (WDX) and XPS. The Ga oxide films obtained were x-ray amorphous. Gas-sensing experiments indicated that the films showed an n-type response to EtOH at a variety of temperatures In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9Category: alcohols-buliding-blocks).

1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective σ-Bond Metathesis in Alkyl-Aryl and Alkyl-Benzyl Yttrium Complexes. New Aryl- and Benzyl-Hydrido Yttrium Derivatives Supported by Amidopyridinate Ligands was written by Lyubov, D. M.;Fukin, G. K.;Cherkasov, A. V.;Shavyrin, Andrei S.;Trifonov, A. A.;Luconi, L.;Bianchini, C.;Meli, A.;Giambastiani, G.. And the article was included in Organometallics in 2009.Formula: C9H10BrNO2 This article mentions the following:

Y dialkyl complexes coordinated by 6-aryl-substituted amidopyridinate ligands undergo selective intramol. sp² or sp³ C-H bond activation. Upon treatment with PhSiH₃ of the resulting Y-C(alkyl, aryl) or Y-C(alkyl,benzyl) systems, a σ-bond metathesis reaction takes place selectively at the Y-C(alkyl) bond, generating rare dimeric aryl-hydrido (e.g., I) or benzyl-hydrido Y complexes, resp. I was characterized by x-ray crystallog. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9Formula: C9H10BrNO2).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C9H10BrNO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fortification of buttermilk with calcium, magnesium and whey proteins was written by Ziarno, Malgorzata;Zareba, Dorota;Piskorz, Jolanta. And the article was included in Zywnosc in 2009.COA of Formula: C6H20CaO11 This article mentions the following:

The preparation of buttermilk fortified with Ca and Mg salts and whey protein concentrate (WPC-68) was studied. Different amounts of Ca lactate or citrate, Mg gluconate or hydroaspartate, and WPC or their mixtures were added to milk samples. The impact on milk thermal stability during 15-s re-pasteurization at 74°C and resulting pH was determined Protein clots were formed after the milk thermal processing. When a mixture of Ca citrate, Mg hydroaspartate, and Mg gluconate was used, it was possible to fortify the milk at least to 72 mg% Ca and ∼30 mg% Mg. The addition of the 2 Mg salts did not coagulate the milk proteins during re-pasteurization and the active acidity was pH >6.52. Buttermilk was then produced under laboratory conditions from the milk fortified according to the above procedure with the additives mixed with milk before re-pasteurization (74°C/15 s). The buttermilk sensory and physicochem. properties deteriorated during 14-day refrigerated storage at 6°C. The largest changes were found in buttermilk samples fortified with Ca citrate, Mg gluconate, and WPC. The best fortified buttermilk was made with Ca salts, Mg hydroaspartate, and WPC. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5COA of Formula: C6H20CaO11).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C6H20CaO11

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The synthesis of benzimidazoles via a recycled palladium catalyzed hydrogen transfer under mild conditions was written by Guan, Qianqian;Sun, Qi;Wen, Lixian;Zha, Zhenggen;Yang, Yu;Wang, Zhiyong. And the article was included in Organic & Biomolecular Chemistry in 2018.Quality Control of (2-Bromo-5-chlorophenyl)methanol This article mentions the following:

An efficient synthesis of benzimidazoles I [R¹ = Me, Ph, 2-thienyl, etc.; R² = H, Me, CF₃; R³ = H, Me, Ph, 2-pyridyl, 3-Me-2-pyridyl] was developed via recycled palladium-catalyzed hydrogen-transfer reaction of N-substituted-2-nitroanilines and alcs. The reaction was carried out smoothly under mild conditions that afforded variety of benzimidazoles I with good to excellent yields. The palladium catalyst was recovered easily and reused six times with great catalytic activity. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Quality Control of (2-Bromo-5-chlorophenyl)methanol).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of (2-Bromo-5-chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiral Imidazo[1,5-a]pyridine-Oxazolines: A Versatile Family of NHC Ligands for the Highly Enantioselective Hydrosilylation of Ketones was written by Chinna Ayya, Swamy .P.;Varenikov, Andrii;de Ruiter, Graham. And the article was included in Organometallics in 2020.HPLC of Formula: 171032-87-4 This article mentions the following:

Herein the authors report the synthesis and application of a versatile class of N-heterocyclic carbene ligands based on an imidazo[1,5-a]pyridine-3-ylidine backbone that is fused to a chiral oxazoline auxiliary. The key step in the synthesis of these ligands involves the installation of the oxazoline functionality via a microwave-assisted condensation of a cyano-azolium salt with a wide variety of 2-amino alcs. The resulting chiral bidentate NHC-oxazoline ligands form stable complexes with Rh(I) that are efficient catalysts for the enantioselective hydrosilylation of structurally diverse ketones. The corresponding secondary alcs. are isolated in good yields (typically >90%) with good to excellent enantioselectivities (80-95% ee). The reported hydrosilylation occurs at ambient temperatures (40°), with excellent functional group tolerability. Even ketones bearing heterocyclic substituents (e.g., pyridine or thiophene) or complex organic architectures are hydrosilylated efficiently, which is discussed further. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4HPLC of Formula: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.HPLC of Formula: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Marrying the incompatible for better: Incorporation of hydrophobic payloads in superhydrophilic hydrogels was written by Boon-in, Supissra;Theerasilp, Man;Crespy, Daniel. And the article was included in Journal of Colloid and Interface Science in 2022.HPLC of Formula: 4074-88-8 This article mentions the following:

The entrapment of lyophobic in superhydrophilic hydrogels is challenging because of the intrinsic incompatibility between hydrophobic and hydrophilic mols. To achieve such entrapment without affecting the hydrogel’s formation, the electrospinning of nanodroplets or nanoparticles with a water-soluble polymer could reduce the incompatibility through the reduction of interfacial tension and the formation of a barrier film preventing coalescence or aggregation. Nanodroplets or nanoparticles dispersion are electrospun in the presence of a hydrophilic polymer in hydrogel precursors. The dissolution of the hydrophilic nanofibers during electrospinning allows a redispersion of emulsion droplets and nanoparticles in the hydrogel’s matrix. Superhydrophilic hydrogels with well-distributed hydrophobic nanodroplets or nanoparticles are obtained without detrimentally imparting the viscosity of hydrogel’s precursors and the mech. properties of the hydrogels. Compared with the incorporation of droplets without electrospinning, higher loadings of hydrophobic payload are achieved without premature leakage. This concept can be used to entrap hydrophobic agrochems., drugs, or antibacterial agents in simple hydrogels formulation. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8HPLC of Formula: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hydrogen Transfer-Mediated Multicomponent Reaction for Direct Synthesis of Quinazolines by a Naphthyridine-Based Iridium Catalyst was written by Tan, Zhenda;Fu, Zhongxin;Yang, Jian;Wu, Yang;Cao, Liang;Jiang, Huanfeng;Li, Juan;Zhang, Min. And the article was included in iScience in 2020.Synthetic Route of C8H9NO3 This article mentions the following:

The development of a novel 2-(4-methoxyphenyl)-1,8-naphthyridine-based iridium (III) complex is reported, which exhibits excellent catalytic performance toward a new hydrogen transfer-mediated annulation reaction of 2-nitrobenzylic alcs. R-2-NO₂C₆H₃CHR¹OH (R = H, 5-Me, 3-Me, 5-MeO, 5-Cl, 4-Br, etc.; R¹ = H, Me, Ph) with alcs. R²CH₂OH (R² = C₆H₅, 3-ClC₆H₄, 4-CNC₆H₄, 1-naphthyl, 3-pyridyl, hexyl, etc.) and ammonia. The catalytic transformation proceeds with the striking features of good substrate and functional group compatibility, high step and atom efficiency, no need for addnl. reductants, and liberation of H₂O as the sole byproduct, which endows a new platform for direct access to valuable quinazolines I (R = H, 6-Me, 6-OMe, 7-Br, 4-Me, etc.). Mechanistic investigations suggest that the non-coordinated N-atom in the ligand serves as a side arm to significantly promote the condensation process by hydrogen bonding. In the experiment, the researchers used many compounds, for example, (3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8Synthetic Route of C8H9NO3).

(3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C8H9NO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Practical resolution of racemic trans-2-benzylaminocyclohexanol with di-p-toluoyl-L-tartaric acid via diastereomeric salt formation based on the Pope and Peachey method was written by Ogawa, Ryuji;Fujino, Toshihiro;Hirayama, Noriaki;Sakai, Kenichi. And the article was included in Tetrahedron: Asymmetry in 2008.HPLC of Formula: 40571-86-6 This article mentions the following:

A new resolution process for racemic trans-2-(benzylamino)cyclohexanol, a key intermediate for chiral pharmaceuticals, was investigated. Di-p-toluoyl-L-tartaric acid was found to be a new practical resolving agent in terms of stability and productivity of the resolution system. Resolution conditions were optimized based on the Pope and Peachey method, and the best result was obtained when HCl was added to the resolution system as a supplemental acid; amino alc./tartaric acid/HCl = 1.0/0.6/0.4 (mol/mol/mol) (92% yield, 99.5% de, 92% resolution efficiency). In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6HPLC of Formula: 40571-86-6).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 40571-86-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts