Month: February 2023

A bagasse-supported magnetic manganese dioxide nanoparticle: applications in the selective aerobic oxidation of alcohols and one-pot tandem oxidative synthesis of quinazolinones was written by Rashidi Vahid, Adina;Hajishaabanha, Fatemeh;Shaabani, Shabnam;Farhid, Hassan;Shaabani, Ahmad. And the article was included in Journal of the Iranian Chemical Society in 2022.Electric Literature of C7H7ClO This article mentions the following:

Magnetic manganese dioxide nanoparticles (MnO₂-Fe₃O₄) were coated on sugarcane bagasse as a sugar industrial waste and bio-support (MnO₂-Fe₃O₄@bagasse) via an in situ reduction strategy, in which potassium permanganate was used as the precursor of MnO₂ and sugarcane bagasse as a bio-support and reducing agent of KMnO4. The synthesized bio-based catalyst was characterized by X-ray diffraction, thermogravimetric anal., inductively coupled plasma optical emission spectroscopy, SEM, energy dispersive spectroscopy, Brunauer-Emmett-Teller surface area anal., and vibrating sample magnetometer anal. The catalyst was successfully utilized in the selective aerobic oxidation of primary and secondary benzylic alcs. R¹CH(OH)R² (R¹ = Ph, 4-nitrophenyl, 2,4-dichlorophenyl, 3-phenylpropyl, etc.; R² = H, Me, Ph, 2-oxo-2-phenylethyl) to their corresponding carbonyl compounds R¹C(O)R² and one-pot tandem oxidative synthesis of 2-(substituted)quinazoline-4(3H)-ones I (R³ = Ph, 3-methoxyphenyl, 4-nitrophenyl, 2,4-dichlorophenyl, etc.) from the o-aminobenzamide and aromatic alcs. R³CH₂OH in the absence of oxidizing reagent or initiator. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Electric Literature of C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Electric Literature of C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemical composition of three extracts of Bursera graveolens was written by Yukawa, Chiyoki;Imayoshi, Yuriko;Iwabuchi, Hisakatsu;Komemushi, Sadao;Sawabe, Akiyoshi. And the article was included in Flavour and Fragrance Journal in 2006.Electric Literature of C10H22O3 This article mentions the following:

Three different extracts were separated by di-Et ether extraction, simultaneous steam distillation extraction and roasted aroma extraction (dry distillation) from Bursera graveolens. It was possible to identify 100 compounds in the three different extracts by GC-MS. The odor-active compounds present in the extracts were evaluated by gas chromatog.-olfactometry (GC-O). It was estimated that mono- or sesquiterpenoids contributed to woody, herbal and minty aromas of the woody material of B. graveolens. On the other hand, the roast aroma produced by burning chips included several aroma compounds, such as cyclotene and vanillin. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Electric Literature of C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Green Extraction of Cork Bioactive Compounds Using Natural Deep Eutectic Mixtures was written by Freitas, David S.;Rocha, Diana;Castro, Tarsila G.;Noro, Jennifer;Castro, Vania I. B.;Teixeira, Marta A.;Reis, Rui L.;Cavaco-Paulo, Artur;Silva, Carla. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Recommanded Product: 111-46-6 This article mentions the following:

Quercus suber cork generates bioactive components, such as phenolic acids, terpenoids, and tannins, with excellent biol. properties, including antioxidant, anti-inflammatory, and antiaging activities. Aiming to design environmentally benign processes to eliminate, or reduce, the use of toxic chems., we propose the green extraction of bioactives from cork using natural deep eutectic solvents (NADES). Several deep eutectic mixtures were developed, through the mixture of natural compounds, namely, lactic acid, glycerol, ethylene glycol, sodium citrate, and sodium lactate, chosen according to their origin, toxicity, biocompatibility, polarity, and pH. The results revealed higher extraction yields when using NADES instead of harsh solvents like dioxane, with the extraction process governed by several phys.-chem. parameters, including pH, polarity, viscosity, and d., and also by the method of extraction Acidic NADES composed of lactic acid and glycerol, or sodium citrate, extracted a greater amount of aromatic compounds, terpenoids, and fatty acids and their derivatives More basic eutectic mixtures, composed of sodium lactate and a polyol (ethylene glycol or glycerol), extracted predominantly low mol. weight polar compounds The extracts range encompassed by the developed NADES, together with the associated nontoxicity, low price, and ease of preparation, establish these solvents as a green approach to extract high added-value compounds from cork. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Recommanded Product: 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hydrogel of poly (SSNa-cross-TeEGDMA): preparation, characterization, and Swelling behavior was written by Bradai, Masika;Ould Kada, Seghier;Sebba, Fatima Zohra;Sebti, Houari. And the article was included in Pharma Chemica in 2016.Formula: C16H26O7 This article mentions the following:

Series of novel hydrogels based on sodium styrene sulfonate(SSNa) and tetraethylene glycol dimethacrylate (TeEGDMA) copolymers, were prepared by free radical crosslinking copolymerization and were characterized using Spectra of Fourier transform IR spectroscopy (FTIR), and differential scanning calorimetry (DSC). The swelling properties of these hydrogels were achieved in distilled water at different pH at 25°C, the results showed that the swelling ratio are proportional to the sodium styrene sulfonate (SSNa) percent molar composition of 40, 50 and 80 incorporated in each hydrogel, The values swelling ratio of the basic medium are higher than those observed in acidic and neutral medium. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Comparative analysis of chemical profiles and antioxidant activities of essential oils obtained from species of Lippia L. by chemometrics was written by de Fatima Alves Nonato, Carla;Camilo, Cicera Janaine;Duarte Leite, Debora Odilia;Lucio Albuquerque da Nobrega, Mario Gustavo;Ribeiro-Filho, Jaime;Alencar de Menezes, Irwin Rose;Tavares, Josean Fechine;Martins da Costa, Jose Galberto. And the article was included in Food Chemistry in 2022.COA of Formula: C10H14O This article mentions the following:

Due to the importance of diseases associated with oxidative stress, the search for natural antioxidants proves to be essential. This work aimed to compare the chem. composition and antioxidant potential of essential oils from the genus Lippia L. through chemometric anal. The essential oils were characterized by gas chromatog. coupled with mass spectrometry. Antioxidant potentials were determined by DPPH, ABTS, Deoxyribose and β-carotene protection, Iron chelation and reduction methods. All data were related by multivariate analyzes. Essential oils showed low similar chem. compositions and no statistically significant relationship. These showed relevant antioxidant activity, especially for L. sidoides that obtained IC50 of 5.22 ± 0.08μg/mL in ABTS capture. Multivariate analyzes showed the effectiveness of L. alba compounds to DPPH scavenging, Fe3+ reduction and β-carotene protection, and L. gracilis components to deoxyribose protect. Thus, studies proving the antioxidant potential of Lippia compounds against oxidative stress and their use in food conservation are fundamental. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2COA of Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Catalytic alcohol oxidation using cationic Schiff base manganese^III complexes with flexible diamino bridge was written by Neshat, Abdollah;Osanlou, Farzane;Kakavand, Meysam;Mastrorilli, Piero;Schingaro, Emanuela;Mesto, Ernesto;Todisco, Stefano. And the article was included in Polyhedron in 2021.Application of 1777-82-8 This article mentions the following:

Four Schiff base manganese(III) complexes with derivatives of [(R,R)-N,N’-bis(salicylidene)-1,2-cyclohexanediaminato] including substituents on salicylaldehyde such as 3-methoxy, 3,5-di-tert-Bu and 3,5-chloro were synthesized and characterized using a combination of IR, UV-Vis, and HR ESI-MS techniques. The catalytic activity of these complexes was tested in the oxidation of 1-phenylethanol to acetophenone, revealing very good performances for all of the four manganese complexes. The catalytic reactions were carried out in the presence of tert-Bu hydroperoxide (TBHP) as oxidant and imidazole as co-catalyst. Complex Mn-4, bearing electron withdrawing [(R,R)-N,N’-bis(3,5-di-chloro-salicylidene)-1,2-cyclohexanediaminato] ligand was the most stable of the tested Mn(III) complexes and was selected for the oxidation of several primary and secondary alcs. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Application of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of inhomogeneous spatial distribution of aroma compounds on perceived aroma intensity and human eating behavior for neutral pH gels was written by Nakao, Satomi;Ishihara, Sayaka;Nakauma, Makoto;Funami, Takahiro. And the article was included in Food Science and Technology Research in 2013.Related Products of 5743-47-5 This article mentions the following:

Effects of inhomogeneous spatial distribution of aroma compounds were investigated on the perceived aroma intensity and human eating behavior using polysaccharide gels as a food model. Gels tested were structured using gel-in-gel configuration to create different degrees of inhomogeneous spatial aroma distribution, and their pH values were set at neutral (6.7 – 6.8). There were no differences in mech. properties between the structured gels. A greater degree of inhomogeneous spatial aroma distribution increased the perceived aroma intensity, increased the duration of oral processing and suprahyoid musculature activity during oral processing, decreased the particle size of the bolus, and increased the saliva content in the bolus. Effects of pH were compared with our previous report using the same exptl. design but different pH (approx. 4.2), confirming a similar trend in the results. A strategy of food structure design for enhanced perceived aroma intensity and human eating behavior was suggested regardless of gel pH. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5Related Products of 5743-47-5).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 5743-47-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A General, Multimetallic Cross-Ullmann Biheteroaryl Synthesis from Heteroaryl Halides and Heteroaryl Triflates was written by Kang, Kai;Loud, Nathan L.;DiBenedetto, Tarah A.;Weix, Daniel J.. And the article was included in Journal of the American Chemical Society in 2021.Synthetic Route of C9H10BrNO2 This article mentions the following:

A new, general approach to biheteroaryls: the Ni- and Pd-catalyzed multimetallic cross-Ullmann coupling of heteroaryl halides with triflates. An array of 5-membered, 6-membered and fused heteroaryl bromides and chlorides, as well as aryl triflates derived from heterocyclic phenols proved to be viable substrates in this reaction (62 examples, 63 ± 17% average yield). The generality of this approach to biheteroaryls were further demonstrated in 96-well plate format at 10μmol scale. An array of 96 possible products provided >90% hit rate under a single set of conditions. Further, low-yielding combinations was rapidly optimized with a single “Toolbox Plate” of ligands, additives and reductants. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9Synthetic Route of C9H10BrNO2).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C9H10BrNO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

S_N2 Reaction of sulfur nucleophiles with hindered sulfamidates: Enantioselective synthesis of α-methylisocysteine was written by Avenoza, Alberto;Busto, Jesus H.;Jimenez-Oses, Gonzalo;Peregrina, Jesus M.. And the article was included in Journal of Organic Chemistry in 2006.Recommanded Product: 29364-29-2 This article mentions the following:

The work described here demonstrates that the five-membered cyclic α-methylisoserine-derived sulfamidate (I) behaves as an excellent chiral building block for the ring-opening reaction by S_N2 attack with sulfur nucleophiles at the quaternary carbon. As a synthetic application of this methodol., and to show that this sulfamidate is a valuable starting material, the synthesis of two new α-methylisocysteine derivatives has been carried out to cover the lack of α- and β-methylated amino acids that incorporate the cysteine or isocysteine skeleton. These compounds are two new α,α-disubstituted β-amino acids (β^2,2-amino acids), and the synthetic routes involve nucleophilic ring opening followed by acid hydrolysis. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Recommanded Product: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Improved and ′Nitrosamines Free′ Process for the Preparation of an α4β2 Neuronal Nicotinic Acetylcholine Receptor Agonist-Varenicline Tartrate was written by Goura, Ramesh;Katari, Naresh Kumar;Ramprasad, A. K.;Rebelli, Pradeep;Surendra Babu, Manabolu Surya. And the article was included in Polycyclic Aromatic Compounds.Application of 230615-52-8 This article mentions the following:

An improvised and efficient approach for synthesis of α4β2 nicotinic acetylcholine receptor subtype agonist, Varenicline tartrate free from the ′N-nitrosamines′ has been described. The approach involves an improved process for a key intermediate (7,8-dinitro-4,5-dihydro-1H-1,5-methanobenzo[d] azepin-3(2H)-yl)-2,2,2-trifluoro ethanone free from potential genotoxic impurities. Compound is converted into Varenicline base in a single pot process with improved overall yield and quality. Further, Varenicline base is converted into Varenicline tartrate by acid addition salt which provides in quant. yield. This improved process consists of tech. innovations/improvements which eliminate the probability for the formation of critical impurities such as dinitro nitroso impurity , diamino nitroso impurity and varenicline nitroso impurity and other genotoxic impurities such as mono nitro impurity and meta dinitro impurity in the final drug substance and provides ′Nitrosamines free′ varenicline tartrate with good quality and yield. In the experiment, the researchers used many compounds, for example, 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8Application of 230615-52-8).

2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 230615-52-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts