Month: February 2023

Oligomers as Triggers for Responsive Liquid Crystals was written by Kim, Young-Ki;Raghupathi, Krishna R.;Pendery, Joel S.;Khomein, Piyachai;Sridhar, Uma;de Pablo, Juan J.;Thayumanavan, S.;Abbott, Nicholas L.. And the article was included in Langmuir in 2018.Recommanded Product: 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:

We report an investigation of the influence of aqueous solutions of amphiphilic oligomers on the ordering of micrometer-thick films of thermotropic liquid crystals (LCs), thus addressing the gap in knowledge arising from previous studies of the interactions of monomeric and polymeric amphiphiles with LCs. Specifically, we synthesized amphiphilic oligomers (with decyl hydrophobic and pentaethylene glycol hydrophilic domains) in monomer, dimer, and trimer forms, and incubated aqueous solutions of the oligomers against nematic films of 4′-pentyl-4-biphenylcarbonitrile (5CB). All amphiphilic oligomers caused sequential surface-driven orientational (planar to homeotropic) and then bulk phase transitions (nematic to isotropic) with dynamics depending strongly on the degree of oligomerization. The dynamics of the orientational transitions accelerated from monomer to trimer, consistent with the effects of an increase in adsorption free energy. The mechanism underlying the orientational transition, however, involved a decrease in anchoring energy and not change in the easy axis of the LC. In contrast, the rate of the phase transition induced by absorption of oligomers into the LC decreased from monomer to trimer, suggesting that constraints on configurational degrees of freedom influence the absorption free energies of the oligomers. Interestingly, the oligomer-induced transition from the nematic to isotropic phase of 5CB was observed to nucleate at the aqueous-5CB interface, consistent with surface-induced disorder underlying the above-reported decrease in anchoring energy caused by the oligomers. Finally, we provided proof-of-concept experiments of the triggering of LCs using a trimeric amphiphile that is photocleaved by UV illumination into monomeric fragments. Overall, our results provide insight into the rational design of oligomers that can be used as triggers to create responsive LCs. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Recommanded Product: 3-(Hydroxymethyl)-4-nitrophenol).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 3-(Hydroxymethyl)-4-nitrophenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Evaluation of three different decontamination techniques on biofilm formation, and on physical and chemical properties of resin composites was written by Andre, Carolina Bosso;dos Santos, Andressa;Pfeifer, Carmem Silvia;Giannini, Marcelo;Girotto, Emerson Marcelo;Ferracane, Jack Liborio. And the article was included in Journal of Biomedical Materials Research, Part B: Applied Biomaterials in 2018.Synthetic Route of C16H26O7 This article mentions the following:

Objectives : This study evaluated three different sterilization/disinfection techniques for resin composites on bacterial growth and surface modification after decontamination. Methods : Two resin composites were sterilized/disinfected with three different techniques: UV light, 1% chloramine T, and 70% ethanol. Four different times were used for each technique to determine the shortest time that the solution or UV light was effective. The influence of sterilization/disinfection technique on bacterial growth was evaluated by analyzing the metabolic activity, using the AlamarBlue® assay, bacterial viability, and SEM images from biofilms of Streptococcus mutans. The surface change, after the process, was analyzed with ATR/FTIR and SEM images. The solutions used for decontamination (1% chloramine-T and 70% ethanol) were analyzed with ¹H-NMR to identify any resin compounds leached during the process. Results : One minute of decontamination was efficient for all three methods tested. Chloramine-T increased the surface porosity on resin composites, no changes were observed for UV light and 70% ethanol, however, ¹H-NMR identified leached monomers only when 70% ethanol was used. No chem. change of the materials was found under ATR/FTIR analyses after the decontamination process. Chloramine-T, with no previous wash, increased the bacterial viability for both resin composites and increased the bacterial metabolism for the resin composite without fluoride. Conclusion : UV light had no interference on the resin composites properties tested using 1 min of exposure compared to the other decontamination methods. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2017. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Synthetic Route of C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Structure-based design, synthesis, and biological evaluation of novel piperine-resveratrol hybrids as antiproliferative agents targeting SIRT-2 was written by Tantawy, Ahmed H.;Meng, Xiang-Gao;Marzouk, Adel A.;Fouad, Ali;Abdelazeem, Ahmed H.;Youssif, Bahaa G. M.;Jiang, Hong;Wang, Man-Qun. And the article was included in RSC Advances in 2021.Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

A series of novel piperine-resveratrol hybrids 5a-h was designed, synthesized, and structurally elucidated by IR, and ¹H, ¹³C, and ¹⁹F NMR. Antiproliferative activities of 5a-h were evaluated by NCI against sixty cancer cell lines. Compound 5b, possessing resveratrol pharmacophoric phenolic moieties, showed a complete cell death against leukemia HL-60 (TB) and Breast cancer MDA-MB-468 with growth inhibition percentage of -0.49 and -2.83, resp. In addition, 5b recorded significant activity against the other cancer cell lines with growth inhibition percentage between 80 to 95. New 5a-h hybrids were evaluated for their inhibitory activities against Sirt-1 and Sirt-2 as mol. targets for their antiproliferative action. Results showed that compounds 5a-h were more potent inhibitors of Sirt-2 than Sirt-1 at 5 μm and 50 μm. Compound 5b showed the strongest inhibition of Sirt-2 (78 ± 3% and 26 ± 3% inhibition at 50 μM and 5 μM, resp.). Investigation of intermol. interaction via Hirschfeld surface anal. indicates that these close contacts are mainly ascribed to the O-H ···O hydrogen bonding. To get insights into the Sirt-2 inhibitory mechanism, a docking study was performed where 5b was found to fit nicely inside both extended C-pocket and selectivity pocket and could compete with the substrate acyl-Lys. Another possible binding pattern showed that 5b could act by partial occlusion of the NAD+ C-pocket. Collectively, these findings would contribute significantly to better understanding the Sirt-2 inhibitory mechanism in order to develop a new generation of refined and selective Sirt-2 inhibitors. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of long-term consumption of poultry egg products on growth, body composition, and liver gene expression in zebrafish, Danio rerio was written by Williams, Michael B.;Palmer, Joseph W.;Chehade, Sophie B.;Hall, Alex J.;Barry, Robert J.;Powell, Mickie L.;Harris, Melissa L.;Sun, Liou Y.;Watts, Stephen A.. And the article was included in Current Developments in Nutrition in 2021.Category: alcohols-buliding-blocks This article mentions the following:

Poultry eggs are a low-cost, high-protein nutrient package that can be consumed as part of quality diets. However, consumption of poultry egg products is historically contentious, which highlights the importance of investigating impacts of long-term egg consumption on metabolic health. Our study utilized the zebrafish, Danio rerio, a newly defined model of human metabolic health, to understand the metabolic consequence of consuming egg products in lieu of other well-described protein sources. Reference diets were formulated to contain multisource protein with casein and fish protein hydrolyzate (CON; control protein sources), the protein sources that have been historically utilized in numerous reference diets. These proteins were then partially replaced with either whole egg (WE; protein and lipid source), egg white (EW; protein source), wheat gluten (WG; cereal protein source), or a high-lipid-content diet containing a multisource protein with casein and fish protein hydrolyzate (HFCON; isonitrogenous and isolipidic with the WE diet) in a 34-wk trial (n = 8 tanks, 10 fish per tank). Daily feeding was initiated at the early juvenile life stage and terminated at the late reproductive adult stage. The amino acid composition of control vs. egg product diets did not vary substantially, although methionine and lysine were apparently limiting in fish fed WG. At termination, fish fed EW as the protein source had weight gain and body composition similar to those fed the CON diet. Fasting and postprandial blood glucose did not differ between any dietary treatment. Assessment of the liver transcriptome using RNAseq revealed no differential gene expression between zebrafish fed CON or WE diets. Zebrafish fed WG had lower weight gain in males. Long-term consumption of egg products promoted metabolic health equal to that of historically relevant proteins. These data support the value of egg products for maintaining long-term metabolic health in animal diets. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Category: alcohols-buliding-blocks).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study was written by Bordier, Valentine;Teysseire, Fabienne;Senner, Frank;Schlotterbeck, Gotz;Drewe, Jurgen;Beglinger, Christoph;Wolnerhanssen, Bettina K.;Meyer-Gerspach, Anne Christin. And the article was included in International Journal of Molecular Sciences in 2022.Category: alcohols-buliding-blocks This article mentions the following:

The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatog.-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Category: alcohols-buliding-blocks).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alkyl Carbagermatranes Enable Practical Palladium-Catalyzed sp²-sp³ Cross-Coupling was written by Xu, Meng-Yu;Jiang, Wei-Tao;Li, Ying;Xu, Qing-Hao;Zhou, Qiao-Lan;Yang, Shuo;Xiao, Bin. And the article was included in Journal of the American Chemical Society in 2019.Category: alcohols-buliding-blocks This article mentions the following:

Pd-catalyzed cross-coupling reactions have achieved tremendous accomplishments in the past decades. However, C(sp³)-hybridized nucleophiles generally remain as challenging coupling partners due to their sluggish transmetalation compared to the C(sp²)-hybridized counterparts. While a single-electron-transfer-based strategy using C(sp³)-hybridized nucleophiles had made significant progress recently, fewer breakthroughs have been made concerning the traditional two-electron mechanism involving C(sp³)-hybridized nucleophiles. In this report, we present a series of unique alkyl carbagermatranes that were proven to be highly reactive in cross-coupling reactions with our newly developed electron-deficient phosphine ligands. Generally, secondary alkyl carbagermatranes show slightly lower, yet comparable activity to its Sn analog. Meanwhile, primary alkyl carbagermatranes exhibit high activity, and they were also proved stable enough to be compatible with various reactions. Chiral secondary benzyl carbagermatrane gave the coupling product under base/additive-free conditions with its configuration fully inversed, suggesting that transmetalation was carried out in an “S_E2(open) Inv” pathway, which is consistent with Hiyama’s previous observation. Notably, the cross-coupling of primary alkyl carbagermatranes could be performed under base/additive-free conditions with excellent functional group tolerance and therefore may have potentially important applications such as stapled peptide synthesis. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Category: alcohols-buliding-blocks).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Determination of ospemifene in human plasma by LC-MS/MS and its application to a human pharmacokinetic study was written by Yadlapalli, Siva Sankara Rao;Katari, Naresh Kumar;Manabolu Surya, Surendra Babu. And the article was included in Biomedical Chromatography in 2019.Synthetic Route of C24H23ClO2 This article mentions the following:

A highly sensitive, specific and rapid liquid chromatog.-tandem mass spectrometry (LC-MS/MS) anal. method has been developed and validated for the determination of ospemifene in human plasma using ospemifene-d4 as an internal standard Solid-phase extraction technique with Phenomenex Strata X-33 μM polymeric sorbent cartridges (30 mg/1 mL) was used to extract the analytes from the plasma. The chromatog. separation was achieved on Agilent Eclipse XDB-Ph, 4.6 × 75 mm, 3.5 μm column using the mobile phase composition of methanol and 20 mM ammonium formate buffer (90:10, volume/volume) at a flow rate of 0.9 mL/min. A detailed method validation was performed as per the US Food and Drug Administration guidelines and the calibration curve obtained was linear (r2 = 99) over the concentration range 5.02-3025 ng/mL. The API-4500 MS/MS was operated under multiple reaction monitoring mode during the anal. The proposed method was successfully applied to a pharmacokinetic study in healthy human volunteers after oral administration of an ospemifene 60 mg tablet under fed conditions. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Synthetic Route of C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Discrete Platinum(II) Metallacycle Harvesting Triplet Excitons for Solution-Processed Deep-Red Organic Light-Emitting Diodes was written by Xing, Hao;Yu, Ying;Liu, Junkai;Qin, Peng;Lam, Jacky Wing Yip;Shi, Bingbing;Xie, Guohua;Tang, Ben Zhong. And the article was included in Advanced Optical Materials in 2022.COA of Formula: C4H10O3 This article mentions the following:

Platinum(II) coordination-driven architectures have exhibited unique features in fabricating functional supramol. materials. By introducing luminescent moieties into the ligand structure, various light-emitting metallacycles and metallacages have been facilely prepared, presenting specific applications in chem. sensing, light-harvesting, and bio-imaging. Except for building up the metal-ligand bonds, the platinum(II) center should also benefit the ultimate luminescence due to its unique photophys. traits. Here, a platinum(II) metallacycle with deep-red emission for solution-processed organic light-emitting diodes is reported. This metallacycle is assembled by mixing a 180° di-Pt(II) acceptor with a pyridyl-decorated ligand functionalized by a deep-red fluorescent emitter. Notably, the platinum(II) acceptor permits the efficient intramol. transfer of all elec. generated singlet and triplet excitons from itself to the fluorescent moiety, which dramatically enhances the external quantum efficiency of the device compared with the one consisting of the sole ligand. The present results reveal the function of platinum(II) metallacycles in light-emitting devices, a finding which should apply to other coordination-driven architectures with versatile properties. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6COA of Formula: C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Derivatives of 1,2,3,4-tetrahydroxybenzene. V. The synthesis of parsley apiole and derivatives was written by Baker, Wilson;Savage, R. I.. And the article was included in Journal of the Chemical Society in 1938.COA of Formula: C7H6O3 This article mentions the following:

2,3-(MeO)₂C₆H₃OH is converted by K₂S₂O₈ into 2,3,1,4-(MeO)₂C₆H₃(OH)₂ (I), a dark oil, which gives 1,2,3,4-C₆H₂(OMe)₄, m. 88-9°; the di-Ac derivative m. 54°. 2,3,4-HO(MeO)₂C₆H₂CO₂H (24 g.) with K₂S₂O₈ in NaOH gives 6.5 g. of 2,5-dihydroxy-3,4-di-methoxybenzoic acid (II), m. 171°; heating at 200° gives I, m. 84-5°. II and Me₂SO₄-KOH give the tetra-Me derivative, m. 87-8°. 2,3,4-(HO)₃C₆H₂CO₂H(80 g.) and CH₂SO₄ in Me₂CO-NaOH give 9-10 g. of 2-hydroxy-3,4-methylenedioxybenzoic acid (III), m. 235° (evolution of CO₂); FeCl₃ gives an intense violet color; Ac derivative, m. 165°. Heating 10 g. of III in quinoline with Cu chromite catalyst at 180° for 2 h. gives 6 g. pyrogallol methylene ether (IV), m. 85°, oxidation of which with K₂S₂O₈ yields methylenedioxyquinol (V), m. about 180° (some decomposition); diacetate, m. 104°. The di-Me ether of V is parsley apione, m. 77-77.5°, identical with that prepared from natural apiole. III (6 g.) with K₂S₂O₈ in NaOH gives 0.3 g. of 2,5-dihydroxy-3,4-methylenedioxybenzoic acid, very pale yellow, m. 250° (decomposition), gives a deep blue FeCl₃ reaction; the di-Me ether is identical with parsley apiolic acid and yields a 1,2-di-Br derivative, m. 97-8°. IV (9 g.) and allyl bromide with K₂CO₃, refluxed 8 h., give 10 g. of 2,3-methylenedioxyphenyl allyl ether, b₂₄ 139-40°; heating at 220° yields 2-hydroxy-3,4-methylenedioxy-1-allylbenzene, b₂₀ 155-6°; oxidation with K₂S₂O₈ gives the 2,5-di-HO derivative, a reddish oil difficult to crystallize, the di-Me ether of which is identical with parsley apiole. Bromoapiole dibromide m. 80-80.5°. Details are given for the preparation of 1-o-benzoylpyrogallol, 2,3-(MeO)₂C₆H₃OBz, pyrogallol 1-Me ether and 4,3,2-HO(MeO)₂C₆H₂CHO. III and Br in AcOH give the 5-Br derivative, with AcOH of crystallization lost at 100°, m. 255° (decomposition). HNO₃ in AcOH gives the 5-NO₂ derivative of III, pale yellow, m. 295° (decomposition); FeCl₃ gives a red color and the yellow NaHCO₃ solution becomes bright orange on adding NaOH. 4-Methyldaphnetin and CH₂SO₄ in Me₂CO-NaOH give the methylene ether, pale yellow, m. 226°; HNO₃ gives the 5 (or 6)-NO₂ derivative, pale yellow, m. 138-9°. 2,3-Dihydroxy-4-methoxybenzaldehyde m. 118-19° instead of 69.5° as given in C. A. 32, 4552.9. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2COA of Formula: C7H6O3).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, conformational studies and enantioselective homogeneous catalytic hydrogenation with CRC-PHOS, and some congeners was written by Comisso, G.;Sega, A.;Sunjic, V.;Lisini, A.. And the article was included in Croatica Chemica Acta in 1981.Name: 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid This article mentions the following:

The lactone of (1S,3R)-1-hydroxy-1-diphenylphosphinomethyl-2,2,3-trimethylcyclopentane-3-carboxylic acid (I, CRC-PHOS), and (1R,3R)-bis(diphenylphosphinoxymethyl)-2,2,3-trimethylcyclopentane (II), were prepared starting from (+)-camphanic and (-)-isocamphoric acid, resp. Their complex salts [RhL₂(NBD)]ClO₄ (L = I, NBD = norbornadiene) and [RhL¹(NBD)]ClO₄ (L¹ = II) were isolated and their catalytic and enantioselective ability tested on some model prochiral carboxylic acids. The asym. bias did not exceed 35% e.e. in either case. Attempts at preparation of the diphosphine congener of II as well as isolation of the phosphinite congener of I failed. NMR LIS study of the conformation in solution of I and model compounds III and IV revealed that I and III possess in their most stable conformations a dihedral angle ψ of 165°, whereas for IV two stable conformations with ψ 200° and 350° are found. These results indicate that bidentate binding of metal to heteroatom X (O, P) in the side chain, and to the tetrahedral O within lactone group is scarcely possible. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Name: 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts