Paired electrolysis enabled annulation for the quinolyl-modification of bioactive molecules was written by You, Shiqi;Ruan, Mengyao;Lu, Cuifen;Liu, Li;Weng, Yue;Yang, Guichun;Wang, Shengchun;Alhumade, Hesham;Lei, Aiwen;Gao, Meng. And the article was included in Chemical Science in 2022.Synthetic Route of C24H23ClO2 This article mentions the following:
A paired electrolysis enabled cascade annulation that enables the efficient synthesis of highly functionalized quinoline-substituted bioactive mols. from readily available starting materials is reported. Using this methodol., two goals, namely, the direct synthesis of quinolines and the introduction of quinoline moieties to bioactive mols., can be simultaneously achieved in one simple operation. The use of electroreduction for the activation of isatin, together with the further anodic oxidation of KI to catalytically result in a cascade annulation, highlight the unique possibilities associated with electrochem. activation methods. This transformation can tolerate a wide range of functional groups and can also be used as a functionalization tactic in pharmaceutical research as well as other areas. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Synthetic Route of C24H23ClO2).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C24H23ClO2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts