Synthesis, in vitro pharmacology and radiosynthesis of N-(cis-4-fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1-thiocarbonamide (VUF 5000), a potential PET ligand for the histamine H3 receptor was written by Windhorst, Albert D.;Timmerman, Henk;Menge, Wiro M. P. B.;Leurs, Rob;Herscheid, Jacobus D. M.. And the article was included in Journal of Labelled Compounds & Radiopharmaceuticals in 1999.COA of Formula: C12H23NO3 This article mentions the following:
The synthesis of VUF 5000, a fluorinated analog of the potent (pA2 value of 8.9 ± 0.1, Ki = 4.3 ± 0.9 nM) histamine H3 receptor antagonist thioperamide is described. After establishing the H3 antagonistic activity of VUF 5000, pA2 value = 9.0 ± 0.2, Ki = 2.3 ±0.5 nM, a four step synthesis for the radiolabelling of VUF 5000 with 18F (half life 110 min) was developed. Within 4 h of the end of the bombardment, [18F]VUF 5000 was obtained with an average radiochem. yield of 23% (decay corrected) and a specific activity > 96.2 TBq/μmol (2.6 Ci/μmol). In the experiment, the researchers used many compounds, for example, tert-Butyl (cis-4-(hydroxymethyl)cyclohexyl)carbamate (cas: 223131-01-9COA of Formula: C12H23NO3).
tert-Butyl (cis-4-(hydroxymethyl)cyclohexyl)carbamate (cas: 223131-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C12H23NO3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts