Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols was written by Wang, Ke;Chen, Hao;Dai, Xinyan;Huang, Xupeng;Feng, Zhiqiang. And the article was included in RSC Advances in 2021.Recommanded Product: 6-Methyl-2-pyridinemethanol This article mentions the following:
Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily available o-nitrobenzamides and alcs. using hydrogen transfer was described. Various quinazolin-4(3H)-ones were obtained in good to high yields. The cascade reaction including alc. oxidation, nitro reduction, condensation, and dehydrogenation occurs without any added reducing or oxidizing agent. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Recommanded Product: 6-Methyl-2-pyridinemethanol).
6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 6-Methyl-2-pyridinemethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts