Overactive bladder syndrome treatment with ospemifene in menopausal patients with vulvovaginal atrophy: improvement of sexuality? was written by Schiavi, Michele Carlo;Sciuga, Valentina;Giannini, Andrea;Vena, Flaminia;D’oria, Ottavia;Prata, Giovanni;Di Tucci, Chiara;Savone, Delia;Aleksa, Natalia;Capone, Carmela;Di Mascio, Daniele;Meggiorini, Maria Letizia;Monti, Marco;Zullo, Marzio Angelo;Muzii, Ludovico;Benedetti Panici, Pierluigi. And the article was included in Gynecological Endocrinology in 2018.Reference of 128607-22-7 This article mentions the following:
The aim of this study was to assess the effectiveness of ospemifene in the improvement of sexual function in postmenopausal women with vulvovaginal atrophy (VVA) affected by overactive bladder syndrome (OAB) or urge urinary incontinence (UUI). One hundred five postmenopausal patients with VVA affected by OAB and/or UUI were enrolled for the study. All patients received ospemifene 60 mg for 12 wk. Clin. examination, 3-d voiding diary and the vaginal health index (VHI) were performed at baseline and at 12 wk. Patients completed the OAB-Q SF, FSFI, FSDS, and SF-36 questionnaires. The patient’s satisfaction was also calculated After 12 wk, the reduction of urinary symptoms was observed The OAB-Q symptoms, OAB-Q (HRQL) score were (55.34 ± 13.54 vs. 23.22 ± 9.76; p < .0001) and (22.45 ± 9.78 vs. 70.56 ± 15.49; p < .0001), before and after treatment. SF-36 questionnaire showed a significant improvement (p < .0001). VHI score increased and the women who regularly practice sexual activity increased after treatment. The total FSFI score increased significantly and the FSDS score changed after 12 wk (p < .0001). The PGI-I after 12 wk showed a total success rate of 90.5%. Ospemifene is an effective potential therapy for postmenopausal women with VVA affected by OAB or UUI improving sexual function and quality of life. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Reference of 128607-22-7).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 128607-22-7
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