Study of Mesalazine Solubility in Ternary Mixtures of Ethanol, Propylene Glycol, and Water at Various Temperatures was written by Rahimpour, Elaheh;Martinez, Fleming;Hemmati, Salar;Ramezani, Amir M.;Jouyban, Abolghasem. And the article was included in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2022.Product Details of 57-55-6 This article mentions the following:
Mesalazine is a low-permeable and low-soluble drug, which makes it a class IV drug in the Biopharmaceutics Classification System. Hence, its solubilization can be helpful for various stages of formulation development. The purpose of this study was to investigate the solubilization manner and thermodn. of mesalazine in ternary solvent combinations of {ethanol (1) + propylene glycol (2) + water (3)} using the shake-flask technique at (298.2-313.2) K. In the following, the math. representation of the acquired solubility data using some popular models was evaluated. The accuracies of the applied models were described by percentages of mean relative deviation (MRD%). Based on obtained results (MRD% < 10.0), it can be concluded that the trained models can adequately predict the solubility of mesalazine in the investigated ternary solvent combinations. The findings also revealed that the solution composition and temperatures greatly influence the solubility of mesalazine. In addition, the thermodn. characteristics of the mesalazine dissolution process indicate that the mesalazine dissolution process is endothermic and entropy-driven. The generating data in the current work also expands the available solubility database for mesalazine in the solvent mixtures In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Product Details of 57-55-6).
1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 57-55-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts