A new synthetic route to chiral 3-aryl-5-ethyl-1,4,2-oxazaphosphorines was written by Metlushka, Kirill E.;Sadkova, Dilyara N.;Nikitina, Kristina A.;Yamaleeva, Zilya R.;Ivshin, Kamil A.;Kataeva, Olga N.;Alfonsov, Vladimir A.. And the article was included in Mendeleev Communications in 2018.Application of 5856-63-3 This article mentions the following:
Diastereoselective synthesis of racemic and enantiopure 3-aryl-5-ethyl-1,4,2-oxazaphosphorines, including those bearing phenolic hydroxyl groups in the exocyclic aromatic fragment, was implemented by the reaction of imines derived from (±)-and (R)-(-)-2-aminobutan-1-ol and (hydroxy)benzaldehydes with tri-Et phosphite and trifluoroacetic acid, followed by the one-pot dealkylation of the intermediate esters. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Application of 5856-63-3).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 5856-63-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts