para-Selective C-H Borylation of Aromatic Quaternary Ammonium and Phosphonium Salts was written by Lu, Shuo;Zheng, Tianyu;Ma, Jiawei;Deng, Zhangming;Qin, Shengmeng;Chen, Yu;Liang, Yong. And the article was included in Angewandte Chemie, International Edition in 2022.Name: 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:
Aromatic ammonium and phosphonium salts are important synthetic intermediates and multifunctional materials, but para-selective functionalization of the aromatic salts remains a challenge. Here authors developed ionic ligand based newly designed “biphenyl-phenanthroline” skeleton and realize the Ir-catalyzed para-selective C-H borylation of seven types of aromatic quaternary ammonium and phosphonium salts. Gram-scale transformation, late-stage elaboration for drug mol., and diversification of borylated products demonstrate the potential utility of this reaction. The mechanistic studies and computational anal. elucidate the origin of para-selectivity. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Name: 2-(Trifluoromethyl)phenethyl alcohol).
2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: 2-(Trifluoromethyl)phenethyl alcohol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts