Iridium-catalyzed asymmetric transfer hydrogenation of aromatic ketones with a cinchona alkaloid derived NNP ligand was written by Li, Linlin;Ma, Nana;Chen, Qian;Sun, Hao;Tian, Jie;Xu, Qian;Li, Chun;Zhang, Lin. And the article was included in Organic & Biomolecular Chemistry in 2022.Electric Literature of C8H9FO This article mentions the following:
An iridium complex generated in situ from [Ir(COD)Cl]2 and a cinchona alkaloid derived NNP ligand has been developed for the asym. transfer hydrogenation of aromatic ketones. In this study, 30 aromatic ketones and heteroaryl ketones were hydrogenated to produce valuable chiral alcs. with up to 99% ee using i-PrOH as the hydrogen source and the solvent. The easily prepared Ir(L8)(COD)Cl also exhibited excellent activity and enantioselectivity in asym. transfer hydrogenation of aromatic ketones with a high S/C ratio (up to 2000). In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Electric Literature of C8H9FO).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C8H9FO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts