Synthesis and antiproliferative evaluation of some 1,4-naphthoquinone derivatives against human cervical cancer cells was written by Kacmaz, Aysecik;Deniz, Nahide Gulsah;Aydinli, Serdar Goksin;Sayil, Cigdem;Onay-Ucar, Evren;Mertoglu, Elif;Arda, Nazli. And the article was included in Open Chemistry in 2019.Reference of 29364-29-2 This article mentions the following:
In the course of biol. properties of quinone derivatives, the N(H)-, S- and S,S-substituted-1,4-naphthoquinones were synthesized by reactions of 2,3-dichloro-1,4-naphthoquinone with different amines (2-morpholinoaniline, tert-Bu 4-aminobenzoate, 4-tertbutylbenzylamine, N-(3-aminopropyl)-2-pipecoline, 2-amino-5,6-dimethylbenzothiazole, N,N’-diphenyl-p-phenylenediamine) and thiolate (sodium 2-methyl-2-propanethiolate). The antiproliferative activities of these compounds against human cervical cancer (HeLa) cells were evaluated by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay. Although all derivatives inhibited cell growth, the most active compound was 2-(tert-butylthio)-3-chloronaphthalene-1,4-dione (IC50 = 10.16μM) against the HeLa cells. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Reference of 29364-29-2).
Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 29364-29-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts