Scandium Triflate Catalyzed Tandem Transfer Hydrogenation and Cyclization Reaction of o-Aminobenzaldehydes and o-Aminoacetophenone with Alcohols was written by Gou, Bo-Bo;Yang, Sen;Sun, Huai-Ri;Jian, Qing-Song;Sharif, Atif;Zhou, Ling;Chen, Jie. And the article was included in Journal of Organic Chemistry in 2021.Quality Control of 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:
An effective Sc-catalyzed transfer hydrogenation and cyclization tandem reaction has been achieved. This process showed excellent functional group compatibility and good yields. A variety of benzoxazines I (R = H, Me; R1 = H, Me, Et; R2 = Me, Ph, naphthalen-1-yl, thiophen-2-ylmethyl, etc.; R1R2 = -(CH2)5-; R3 = H, F, Cl, Me, Br; R4 = H, Me; R5 = H, Me, Cl, Br) were produced with primary or secondary alcs. R2(R3)CH2OH as a hydrogen source. Furthermore, the utility of this newly developed protocol is demonstrated through scaled-up experiment, late-stage modification, and preliminary exploration of enantioselective synthesis. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Quality Control of 2-(4-(Trifluoromethyl)phenyl)ethanol).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of 2-(4-(Trifluoromethyl)phenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts