Occupational methacrylate and acrylate allergy – cross-reactions and possible screening allergens was written by Aalto-Korte, Kristiina;Henriks-Eckerman, Maj-Len;Kuuliala, Outi;Jolanki, Riitta. And the article was included in Contact Dermatitis in 2010.Computed Properties of C10H14O5 This article mentions the following:
Background: Acrylic resin monomers, especially acrylates and methacrylates, are important occupational allergens. Aims: To analyze patterns of concomitant patch test reactions to acrylic monomers in relation to exposure, and to suggest possible screening allergens. Patients/methods: We reviewed the patch test files for the years 1994-2009 at the Finnish Institute of Occupational Health for allergic reactions to acrylic monomers, and analyzed the clin. records of sensitized patients. Results: In a group of 66 patients allergic to an acrylic monomer, the most commonly pos. allergens were three methacrylates, namely ethyleneglycol dimethacrylate (EGDMA), 2-hydroxyethyl methacrylate (2-HEMA) and 2-hydroxypropyl methacrylate (2-HPMA), and an acrylate, namely diethyleneglycol diacrylate (DEGDA). The patterns of concomitant reactions imply that exposure to methacrylates may induce cross-reactivity to acrylates, whereas exposure to acrylates usually does not lead to cross-allergy to methacrylates. Screening for triethyleneglycol diacrylate (TREGDA) in the baseline series was found to be useful, as 3 of 8 patients with diagnosed occupational acrylate allergy might have been missed without the screening. Conclusions: A short screening series of four allergens, EGDMA, DEGDA, 2-HPMA and pentaerythritol triacrylate (PETA), would have screened 93% of our 66 patients: each of the remaining 5 patients reacted to different acrylic monomer(s). In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Computed Properties of C10H14O5).
Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Computed Properties of C10H14O5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts