3-Vinyl oxindole-chromone synthon as a skeletal reconstruction reactant for the synthesis of 2-hydroxy benzoyl pyridones was written by Zhang, Lei;Liu, Ren-Ming;Wang, Wei-Na;Liu, Xiong-Li;Dai, Yi-Feng;Yu, Zhang-Biao;Peng, Li-Jun. And the article was included in New Journal of Chemistry in 2022.Reference of 5856-63-3 This article mentions the following:
The first example of ring-opening and recyclization reaction of 3-vinyl oxindole-chromones I [R1 = H, 4-F, 5-Br, etc.; R2 = H, 5-F, 4-Cl, etc.] as versatile synthons, which can react with ammonia or primary aliphatic amines as binucleophiles was developed, serving as a fruitful strategy for the eco-friendly and atom-economic synthesis of a new family of skeletally diverse 2-hydroxy benzoyl pyridones II [R3 = H, CH2CH2OMe, CH2CH2CN, etc.] with high to excellent yields (70-92%). The advantages of this methodol., including the use of easily available raw materials and the catalyst-free, wide functional group tolerance, and gram-scale synthesis, make the developed methodol. a practical way to access important biol. active 2-hydroxy benzoyl pyridone mols. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Reference of 5856-63-3).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 5856-63-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts