Two-step synthesis technology of ospemifene was written by Zhang, Dan;Lan, Jing;Li, Ling;Luo, Zhen-fu;Zhang, Chun-xue. And the article was included in Xiandai Yaowu Yu Linchuang in 2012.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:
The synthetic process comprises Williamson reaction of 4-hydroxybenzophenone with 2-bromoethanol to obtain 2-(4-benzoylphenoxy)-1-ethanol (with yield of 90% and purity of 95.3%), and Mcmurry reaction of 2-(4-benzoylphenoxy)-1-ethanol with 3-chloropropiophenone to obtain ospemifene (with yield of 70% and purity of >99.5%). The synthetic process is stable, simple, and suitable for industrial production In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts