Synthesis of the first sulfur-35-labeled hERG radioligand was written by Raab, Conrad E.;Butcher, John W.;Connolly, Thomas M.;Karczewski, Jerzy;Yu, Nathan X.;Staskiewicz, Steven J.;Liverton, Nigel;Dean, Dennis C.;Melillo, David G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Related Products of 29364-29-2 This article mentions the following:
The synthesis of the first high specific activity S-35-labeled hERG radioligand, [35S]MK-0499, for use in high-throughput-screening (HTS) assays of drug candidates for hERG interaction is described. The radioligand is prepared by [35S]sulfonylation of a high diastereomeric excess (de) aniline precursor prepared from unlabeled MK-0499. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Related Products of 29364-29-2).
Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 29364-29-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts