Anti-insulin resistance effect of constituents from Senna siamea on zebrafish model, its molecular docking, and structure-activity relationships was written by Nuankaew, Wanlapa;Heemman, Armad;Wattanapiromsakul, Chatchai;Shim, Ji Heon;Kim, Na Woo;Yasmin, Tamanna;Jeong, Seo Yule;Nam, Youn Hee;Hong, Bin Na;Dej-adisai, Sukanya;Kang, Tong Ho. And the article was included in Journal of Natural Medicines in 2021.Recommanded Product: 10083-24-6 This article mentions the following:
Senna siamea has been used as an antidiabetic drug since antiquity. With regard to traditional Thai medicine, the use of S. siamea was described for diabetes therapy. To understand the mol. mechanism regarding insulin resistance. Pure compounds were isolated from wood extract We studied their biol. activities on insulin-resistance using an in vivo zebrafish model. We also performed an in silico study; mol. docking, and in vitro study by taking advantage of the enzyme inhibitory activities of 伪-glucosidase, PTP1B, and DPP-IV. Based on the preliminary investigation that Et acetate and ethanol extracts have potent effects against insulin resistance on zebrafish larvae, five compounds were isolated from two fractions following: resveratrol, piceatannol, dihydropiceatannol, chrysophanol, and emodin. All of the isolated compounds had anti-insulin resistance effects on zebrafish larvae. Resveratrol, piceatannol, and dihydropiceatannol also demonstrated inhibitory effects against 伪-glucosidase. Chrysophanol and emodin inhibited PTP1B activity, while resveratrol showed a DPP-IV inhibition effect via the mol. docking. The results of enzyme assay were similar. In conclusions, S. siamea components demonstrated effects against insulin resistance. The chem. structure displayed identical biol. activity to that of the compounds Therefore, S. siamea wood extract and their components are potential therapeutic options in the treatment of diabetes. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: 10083-24-6).
(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 10083-24-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts