Chemoenzymatic Deracemization of Secondary Alcohols by using a TEMPO-Iodine-Alcohol Dehydrogenase System was written by Mendez-Sanchez, Daniel;Mangas-Sanchez, Juan;Lavandera, Ivan;Gotor, Vicente;Gotor-Fernandez, Vicente. And the article was included in ChemCatChem in 2015.Computed Properties of C8H9ClO This article mentions the following:
A deracemization system for secondary alcs. was established after the anal. of individual steps and their compatibility in one pot. The chem. oxidation and bioreduction occurred in a sequential manner to yield 1-arylethanols and lineal aliphatic alcs. with excellent conversions and enantiomeric excess values. The oxidation step was performed by using 2,2,6,6-tetramethylpiperidin-1-oxyl and iodine. This chem. process was extremely favored by sonication, which allowed quant. formation of the corresponding ketone intermediates after just 1 h. Simple destruction of iodine in the same pot allowed sequential bioreduction of the ketones by using either Prelog or antiPrelog enzymes, which led to the preparation of the enantiopure alcs. in excellent yields. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Computed Properties of C8H9ClO).
(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C8H9ClO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts