Highly efficient NHC-iridium-catalyzed 尾-methylation of alcohols with methanol at low catalyst loadings was written by Lu, Zeye;Zheng, Qingshu;Zeng, Guangkuo;Kuang, Yunyan;Clark, James H.;Tu, Tao. And the article was included in Science China: Chemistry in 2021.Formula: C9H9F3O This article mentions the following:
A highly efficient 尾-methylation of primary and secondary alcs. with methanol was achieved by using bis-N-heterocyclic carbene iridium (bis-NHC-Ir) complexes. Broad substrate scope and up to quant. yields were achieved at low catalyst loadings with only hydrogen and water as byproducts. The protocol was readily extended to the 尾-alkylation of alcs. with several primary alcs. Control experiments, along with DFT calculations and crystallog. studies, revealed that the ligand effect was critical to their excellent catalytic performance, shedded light on more challenging Guerbet reactions with simple alcs. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Formula: C9H9F3O).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C9H9F3O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts