Diverse synthetic approaches towards C1′-branched acyclic nucleoside phosphonates was written by Kalcic, Filip;Dracinsky, Martin;Janeba, Zlatko. And the article was included in Organic & Biomolecular Chemistry in 2021.Reference of 5856-63-3 This article mentions the following:
Herein we describe and compare five convenient approaches leading to key synthetic 6-chloropurine acyclic nucleoside phosphonates (ANPs), e.g. I, bearing the 9-phosphonomethoxyethyl (PME) moiety branched at the C1‘ position. These intermediates can be further vastly diversified into target C1′-branched ANPs bearing either natural or unnatural nucleobases. The importance of C1′-branched ANPs is emphasized by their analogy with C1’-substituted cyclic nucleotides (such as remdesivir, a broad-spectrum antiviral agent) and evaluation of their biol. activity (e.g. antiviral, antineoplastic, and antiprotozoal) will be a tempting subject of further research. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Reference of 5856-63-3).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 5856-63-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts