In vitro and in vivo biocompatibility of novel zwitterionic poly(beta amino)ester hydrogels based on diacrylate and glycine for site-specific controlled drug release was written by Filipovic, Vuk V.;Babic, Marija M.;Godevac, Dejan;Pavic, Aleksandar;Nikodinovic-Runic, Jasmina;Tomic, Simonida Lj.. And the article was included in Macromolecular Chemistry and Physics in 2019.Reference of 4074-88-8 This article mentions the following:
New (β-aminoester) hydrogels (PBAE) based on di(ethylene glycol)diacrylate and glycine are successfully synthesized and characterized for the first time in this work. PBAE macromers are obtained using Michael addition By changing the diacrylate/amine stoichiometric ratio, but maintaining it >1, samples with different chem. structure containing acrylate end-groups are obtained. The hydrogels are synthesized from macromers utilizing free radical polymerization Chem. structure of macromers and hydrogels is confirmed by proton NMR, and Fourier transform infra-red spectroscopy. Swelling and degradation rates in physiol. pH range change notably with pH and monomer molar ratio, validating pH sensitivity and zwitterionic behavior, which can be finely tuned by changing any of these parameters. In vitro cytotoxicity and in vivo acute embryotoxicity in zebrafish (Danio rerio) performed to assess the biocompatibility of the novel hydrogel materials and their degradation products reveal that materials are nontoxic and biocompatible. The Cephalexin in vitro drug release study, at pH values 2.20, 5.50, and 7.40, demonstrates pH-sensitive delivery with the release profiles effectively controlled by pH and the hydrogel composition PBAE hydrogels exhibit great potential for a variety of biomedical applications, including tissue regeneration and intelligent drug delivery systems. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Reference of 4074-88-8).
Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 4074-88-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts