Unusual clinical presentation of allergic contact dermatitis to topical minoxidil was written by Feryel, Amri;Mouna, Korbi;Nesrine, Ben Salah;Hichem, Belhadjali;Jameleddine, Zili. And the article was included in Contact Dermatitis in 2022.Safety of 1,2-Propanediol This article mentions the following:
This article illustrates the unusual clin. presentation of allergic contact dermatitis to topical minoxidil. A 23-yr-old man, with no particular medical history, presented with erythema, itch, increased scaling of the scalp and a cervical lymphadenopathy, without any clin. sign of cutaneous infection. A complete ear, nose, throat examination excluded other cause for this cervical lymphadenopathy. The rest of phys. examination was within normal levels. He used 5% topical minoxidil solution (minoxidil 5%, propylene glycol) as a treatment for an AGA, 3 mo ago. He reported that the lesions on the scalp and the cervical lymphadenopathy first appeared some days after beginning the treatment with minoxidil and became aggravated progressively with subsequent applications. Several attempts of treatment reintroduction induced the recurrence of the same lesions on the scalp associated with cervical lymphadenopathy. ACD to minoxidil or conservatives was suspected. Patch testing was performed with minoxidil 5% solution ‘as is’ and propylene glycol. These tests were applied on the back. The readings were performed on day (D) 2 and D3 according to the ICDRG criteria and showed a pos. reaction for minoxidil 5% solution ‘as is’ (++). The patch test to propylene glycol showed no reaction. Eviction of minoxidil induced a long-lasting remission and complete resolution of the lymphadenopathy. No further episodes were noted after 3 mo of follow-up. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Safety of 1,2-Propanediol).
1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Safety of 1,2-Propanediol
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Alcohols – Chemistry LibreTexts