Erigur, Esra Caner et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2022 | CAS: 111-46-6

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C4H10O3

Design, synthesis and human carbonic anhydrase I, II, IX and XII inhibitory properties of 1,3-thiazole sulfonamides was written by Erigur, Esra Caner;Altug, Cevher;Angeli, Andrea;Supuran, Claudiu T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2022.Synthetic Route of C4H10O3 This article mentions the following:

A series of novel 1,3-thiazole sulfonamides I [R = i-Pr, n-Bu, HOCH2CH2, Ph(CH2)4, etc.] has been designed, synthesized and studied their carbonic anhydrase (CA) inhibitory properties. The inhibition property of four human CA isoforms was investigated: hCA I, II, IX, and XII using the standard drug acetazolamide (AAZ) for comparison. The compounds I showed a wide range of inhibition potency towards the cytosolic enzyme hCA I. Nevertheless, the compounds I (R = n-Pr, i-Pr, HOCH2CHMe, HOCHMeCH2, MeOCH2CH2) have shown higher inhibition potential as compared to acetazolamide (KI = 250 nM). The abundant human cytosolic isoform, hCA II, was strongly inhibited by the most compounds in low nanomolar range (KI < 12.1 nM). On the other hand, almost all novel synthesized compounds have shown weaker inhibition potential as compared to acetazolamide against the tumor membrane- associated isoform hCA IX. Finally, the second tumor membrane-associated isoform, hCA XII, showed a wide range of potency that spanned from 9.3 to 729.6 nM. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Synthetic Route of C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts