A base promoted multigram synthesis of aminoisoxazoles: valuable building blocks for drug discovery and peptidomimetics was written by Chalyk, Bohdan A.;Kandaurova, Inna Y.;Hrebeniuk, Kateryna V.;Manoilenko, Olga V.;Kulik, Irene B.;Iminov, Rustam T.;Kubyshkin, Vladimir;Tverdokhlebov, Anton V.;Ablialimov, Osman K.;Mykhailiuk, Pavel K.. And the article was included in RSC Advances in 2016.Name: 1-Boc-Azetidine-3-yl-methanol This article mentions the following:
A practical multigram metal free synthesis of isoxazole-containing building blocks from com. available amino acids was elaborated. The key reaction was a regioselective [3+2]-cycloaddition of in-situ generated nitrile oxides with alkynes/enamines. The obtained building blocks were used in the preparation of bioactive compounds and peptidomimetics. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3Name: 1-Boc-Azetidine-3-yl-methanol).
1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 1-Boc-Azetidine-3-yl-methanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts