Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution was written by Song, Danzi;Cui, Jiwei;Sun, Huanli;Nguyen, Tri-Hung;Alcantara, Sheilajen;De Rose, Robert;Kent, Stephen J.;Porter, Christopher J. H.;Caruso, Frank. And the article was included in ACS Applied Materials & Interfaces in 2017.Safety of Diethyleneglycoldiacrylate This article mentions the following:
Surface modification is frequently used to tailor the interactions of nanoparticles with biol. systems. In most cases, the chem. nature of the treatments employed to modify the biol. interface (for example attachments of hydrophilic polymers or targeting groups) is the focus of attention. However, isolation of the fundamental effects of the materials employed to modify the interface are often confounded by secondary effects imparted by the underlying substrate. Herein, we demonstrate that polymer replica particles templated from degradable mesoporous silica provide a facile means to evaluate the impact of surface modification on the biol. interactions of nanomaterials, independent of the substrate. Poly(ethylene glycol) (PEG), poly(N-(2 hydroxypropyl)methacrylamide) (PHPMA), and poly(methacrylic acid) (PMA) were templated onto mesoporous silica, crosslinked and the residual particles removed. The resulting nanoparticles, comprising interfacial polymer alone, were then investigated using a range of in vitro and in vivo tests. As expected, the PEG particles showed the best stealth properties and these trends were consistent in both in vitro and in vivo studies. PMA particles showed the highest cell association in cell lines in vitro and were rapidly taken up by monocytes in ex vivo whole blood, properties consistent with the very high in vivo clearance subsequently seen in rats. In contrast, PHPMA particles showed rapid association with both granulocytes and monocytes in ex vivo whole blood, even though in vivo clearance was less rapid than the PMA particles. Rat studies confirmed better systemic exposure for PEG and PHPMA particles when compared to PMA particles. This study provides a new avenue for investigating material-dependent biol. behaviors of polymer particles, irresp. of the properties of the underlying core, and provides insights for the selection of polymer particles for future biol. applications. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Safety of Diethyleneglycoldiacrylate).
Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of Diethyleneglycoldiacrylate
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts