Formulation and evaluation of nasal insert for nose-to-brain drug delivery of rivastigmine tartrate was written by Shaghlil, Lena;Alshishani, Anas;Sa’aleek, Asmaa Abu;Abdalkader, Hamdy;Al-ebini, Yousef. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Recommanded Product: 1,2-Propanediol This article mentions the following:
Nose-to-Brain drug delivery can bypass blood-brain-barrier though the olfactory region using different devices and dosage forms. This work aimed to fabricate and characterize a novel dosage form, nasal inserts, containing rivastigmine tartrate. Four formulas were fabricated using gelatin/HPMC matrix in a different ratios and grades. The fabricated nasal inserts were characterized in terms of phys. appearance, surface pH, diameter and length, mech. properties, and mucoadhesive behavior. The content uniformity, release profile, Ex-vivo permeation of rivastigmine tartrate were also investigated. The release profiles for all nasal inserts were fitted to kinetics model. Phys. and chem. stability of the dosage form were evaluated. F2 appears to have the best sustained release profile, where F1 appears to have the best immediate release profile. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Recommanded Product: 1,2-Propanediol).
1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 1,2-Propanediol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts