Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists was written by Okano, Masahiko;Mito, Jun;Maruyama, Yasufumi;Masuda, Hirofumi;Niwa, Tomoko;Nakagawa, Shin-ichiro;Nakamura, Yoshitaka;Matsuura, Akira. And the article was included in Bioorganic & Medicinal Chemistry in 2009.SDS of cas: 155975-19-2 This article mentions the following:
Synthesis and structure-activity relationship studies of a series of 4-aminoquinazoline derivatives led to the identification of (1 R,2 S)-17, N-[(1R,2S)-2-({2-[(4-chlorophenyl)carbonyl]amino-6-methylquinazolin-4-yl}amino)cyclohexyl]guanidine dihydrochloride, as a highly potent ORL1 antagonist with up to 3000-fold selectivity over the μ, δ, and κ opioid receptors. Mol. modeling clarified the structural factors contributing to the high affinity and selectivity of (1 R,2 S)-17. In the experiment, the researchers used many compounds, for example, tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate (cas: 155975-19-2SDS of cas: 155975-19-2).
tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate (cas: 155975-19-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 155975-19-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts