α-Amino diphenyl phosphonates as novel inhibitors of Escherichia coli ClpP protease was written by Moreno-Cinos, Carlos;Sassetti, Elisa;Salado, Irene G.;Witt, Gesa;Benramdane, Siham;Reinhardt, Laura;Cruz, Cristina D.;Joossens, Jurgen;Van der Veken, Pieter;Brotz-Oesterhelt, Heike;Tammela, Paivi;Winterhalter, Mathias;Gribbon, Philip;Windshugel, Bjorn;Augustyns, Koen. And the article was included in Journal of Medicinal Chemistry in 2019.Synthetic Route of C9H9F3O This article mentions the following:
Increased Gram-neg. bacteria resistance to antibiotics is becoming a global problem, and new classes of antibiotics with novel mechanisms of action are required. The caseinolytic protease subunit P (ClpP) is a serine protease conserved among bacteria that is considered as an interesting drug target. ClpP function is involved in protein turnover and homeostasis, stress response, and virulence among other processes. The focus of this study was to identify new inhibitors of Escherichia coli ClpP and to understand their mode of action. A focused library of serine protease inhibitors based on diaryl phosphonate warheads was tested for ClpP inhibition, and a chem. exploration around the hit compounds was conducted. Altogether, 14 new potent inhibitors of E. coli ClpP were identified. Compounds 85 and 92 emerged as most interesting compounds from this study due to their potency and, resp., to its moderate but consistent antibacterial properties as well as the favorable cytotoxicity profile. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Synthetic Route of C9H9F3O).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C9H9F3O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts