Synthesis of chiral α-benzyl-β2-hydroxy carboxylic acids through iridium-catalyzed asymmetric hydrogenation of α-oxymethylcinnamic acids was written by Li, Ze-Yu;Song, Song;Zhu, Shou-Fei;Guo, Na;Wang, Li-Xin;Zhou, Qi-Lin. And the article was included in Chinese Journal of Chemistry in 2014.Category: alcohols-buliding-blocks This article mentions the following:
An asym. hydrogenation of α-oxymethylcinnamic acids was developed by using chiral spiro phosphine-oxazoline/iridium complexes as catalysts to prepare β2-hydroxycarboxylic acids I [R = C6H5, 3,5-(OCH3)2C6H3, C6H4CH2, etc.; Ar = C6H5, 3,4-(OCH2O)C6H3, 3-H3CO-4-C6H5CH2O-C6H3, etc.] with high reactivity (TON up to 2000) and excellent enantioselectivity (up to 99.5% ee) under mild conditions. By using this highly efficient asym. hydrogenation as a key step, a concise enantioselective total synthesis of natural product homoisoflavone II was accomplished in 7 steps with 59% overall yield. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Category: alcohols-buliding-blocks).
Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts